プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Shenbaga Moorthy B.に依頼

India

Researcher, Writer & Consultant with 17+ Years of Research Experience in Biotechnology and Product Development

プロフィール概要

I am a doctorate (PhD) in life sciences with 17+ years of research experience in academic and biopharma companies. I am experienced in drug product development, characterization, study design, data analysis, results interpretation, scientific writings including, research articles, review articles, book chapters, BLA package, SOPs, protocols and technical reports. My achievements include publishing my research in 18 peer reviewed international journals, 3 book chapters and also presenting at various international conferences.

専門分野

• ★ Biologic & Biosimilar Development
• ★ Technical & Scientific Writing
• ★ Manuscript & Journal Article Writing
• ☆ Analytical Chemistry
• ☆ Spectroscopy
• ☆ UV Spectroscopy
• ☆ Fluorescence Spectroscopy
• ☆ Spectrophotometry
• ☆ Mass Spectrometry
• ☆ Liquid Chromatography/HPLC
• ☆ Thermal Analysis
• ☆ Particle Size Distribution
• ☆ Optical Rotation
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Structural Biology
• ☆ Enzyme Activity Assays
• ☆ Binding Assays
• ☆ Molecular Biology
• ☆ Omics
• ☆ Proteomics
• ☆ Protein Sequencing
• ☆ Biophysics
• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Biomolecular Engineering
• ☆ Protein/Enzyme Engineering
• ☆ Stable Isotope Analysis
• ☆ Book Reviews
• ☆ Pharmacy
• ☆ Pharmacy Education
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Drug Design
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Drug Development
• ☆ Drug Formulation
• ☆ Drug Substance Characterization
• ☆ Solid Form Screening
• ☆ Bioanalytical Testing
• ☆ Drug Stability Testing
• ☆ Vaccine Development
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Survey Design & Methodology
• ☆ Journal Selection
• ☆ Instructional Materials
• ☆ Release Notes
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ White Papers
• ☆ Spec Sheets
• ☆ Case Studies
• ☆ Textbook Content Writing
• ☆ Science Communication
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Systematic Literature Review
• ☆ Copywriting
• ☆ Emails & Newsletters
• ☆ Product Descriptions
• ☆ User Guides & Handbooks
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Medical Writing, Technical Writing, Copywriting, Newswriting, General Proofreading & Editing

Research Feasibility Study, Technology Scouting, Fact Checking, Gap Analysis, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Healthcare Consulting, Scientific and Technical Consulting

Data & AI Predictive Modeling, Statistical Analysis, Data Visualization, Data Processing, Data Insights

Product Development Formulation, Recipe Development, Deformulation, Stability/Shelf Life Testing, Product Evaluation, Product Validation, Manufacturing, Quality Assurance & Control (QA/QC), Product Compliance , Concept Development

職務経験

Purdue University West Lafayette

- 現在

Senior principal investigator

Syngene International Limited

3月 2024 - 12月 2024

Senior Scientific Manager

Biocon Biologics

1月 2019 - 2月 2024

Post-doctoral Fellow

York University

3月 2017 - 12月 2018

Research Scientist

Purdue University

1月 2012 - 5月 2016

学歴

PhD

National University of Singapore

1月 2007 - 12月 2011

M Tech

Anna University

6月 2004 - 7月 2006

B Pharm

The Tamil Nadu Dr. M. G. R. Medical University

7月 1999 - 4月 2003

認定資格

• PhD

  National University of Singapore

  12月 2011 - 現在

出版物

JOURNAL ARTICLE

Hu, R., Hameed, U.F.S., Sun, X., Moorthy, B.S., Zhang, W., Jeffrey, P.D., Zhou, L., Ma, X., Chen, F., Pei, J., et al.(2023). A NR2E1-interacting peptide of LSD1 inhibits the proliferation of brain tumour initiating cells . Cell Proliferation. 56. (1).

Kumar, L., Chandrababu, K.B., Balakrishnan, S.M., Allmendinger, A., Walters, B., Zarraga, I.E., Chang, D.P., Nayak, P., Topp, E.M.(2019). Optimizing the Formulation and Lyophilization Process for a Fragment Antigen Binding (Fab) Protein Using Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry (ssHDX-MS) . Molecular Pharmaceutics. 16. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4485-4495.

Moorthy, B.S., Zarraga, I.E., Kumar, L., Walters, B.T., Goldbach, P., Topp, E.M., Allmendinger, A.(2018). Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations . Molecular Pharmaceutics. 15. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-11.

Moussa, E.M., Panchal, J.P., Moorthy, B.S., Blum, J.S., Joubert, M.K., Narhi, L.O., Topp, E.M.(2016). Immunogenicity of Therapeutic Protein Aggregates . Journal of Pharmaceutical Sciences. 105. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 417-430.

Iyer, L.K., Sacha, G.A., Moorthy, B.S., Nail, S.L., Topp, E.M.(2016). Process and Formulation Effects on Protein Structure in Lyophilized Solids Using Mass Spectrometric Methods . Journal of Pharmaceutical Sciences. 105. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1684-1692.

Chandrasekhar, S., Moorthy, B.S., Xie, R., Topp, E.M.(2016). Thiol-Disulfide Exchange in Human Growth Hormone . Pharmaceutical Research. 33. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1370-1382.

Moorthy, B.S., Ghomi, H.T., Lill, M.A., Topp, E.M.(2015). Structural transitions and interactions in the early stages of human glucagon amyloid fibrillation . Biophysical Journal. 108. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 937-948.

Moorthy, B.S., Iyer, L.K., Topp, E.M.(2015). Characterizing protein structure, dynamics and conformation in lyophilized solids . Current Pharmaceutical Design. 21. (40). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5845-5853.

Moorthy, B.S., Iyer, L.K., Topp, E.M.(2015). Mass spectrometric approaches to study protein structure and interactions in lyophilized powders . Journal of Visualized Experiments. 2015. (98).

Moorthy, B.S., Schultz, S.G., Kim, S.G., Topp, E.M.(2014). Predicting protein aggregation during storage in lyophilized solids using solid state amide hydrogen/deuterium exchange with mass spectrometric analysis (ssHDX-MS) . Molecular Pharmaceutics. 11. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1869-1879.

Krishnamurthy, S., Moorthy, B.S., Xiang, L.X., Shan, L.X., Bharatham, K., Tulsian, N.K., Mihalek, I., Anand, G.S.(2014). Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling . Biophysical Journal. 107. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1426-1440.

Krishnamurthy, S., Moorthy, B.S., Liqin, L., Anand, G.S.(2013). Dynamics of phosphodiesterase-induced cAMP dissociation from protein kinase A: Capturing transient ternary complexes by HDXMS . Biochimica et Biophysica Acta - Proteins and Proteomics. 1834. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1215-1221.

Moorthy, B.S., Anand, G.S.(2012). Multistate allostery in response regulators: Phosphorylation and mutagenesis activate RegA via alternate modes . Journal of Molecular Biology. 417. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 468-487.

Moorthy, B.S., Gao, Y., Anand, G.S.(2011). Phosphodiesterases catalyze hydrolysis of cAMP-bound to regulatory subunit of protein kinase A and mediate signal termination . Molecular and Cellular Proteomics. 10. (2).

OTHER

Hu, R., Hameed, U., Sun, X., Moorthy, B., Zhang, W., Jeffrey, P., Zhou, L., Ma, X., Chen, F., Pei, J., et al.(2021). A NR2E1-Interacting Peptide of LSD1 Inhibits the Proliferation of Brain Tumor Initiating Cells . Research Square.

Hu, R., Hameed, U.F.S., Sun, X., Moorthy, B.S., Zhang, W., Jeffrey, P.D., Zhou, L., Ma, X., Chen, F., Pei, J., et al.(2021). A NR2E1-Interacting Peptide of LSD1 Inhibits the Proliferation of Brain Tumor Initiating Cells . SSRN.

Hu, R., Hameed, U.F.S., Sun, X., Moorthy, B.S., Zhang, W., Jeffrey, P.D., Zhou, L., Ma, X., Chen, F., Pei, J., et al.(2021). A NR2E1-Interacting Peptide of LSD1 Inhibits the Proliferation of Brain Tumor Initiating Cells . SSRN.

BOOK CHAPTER

Moorthy, B.S., Xie, B., Moussa, E.M., Iyer, L.K., Chandrasekhar, S., Panchal, J.P., Topp, E.M.(2015). Effect of hydrolytic degradation on the in vivo properties of monoclonal antibodies . Biobetters: Protein Engineering to Approach the Curative. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 105-135.

BOOK

Moorthy, B.S., Xie, B., Moussa, E.M., Iyer, L.K., Chandrasekhar, S., Panchal, J.P., Topp, E.M.(2015). Effect of hydrolytic degradation on the in vivo properties of monoclonal antibodies . AAPS Advances in the Pharmaceutical Sciences Series. 19. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 105-135.

Moorthy, B.S., Xie, B., Moussa, E.M., Iyer, L.K., Chandrasekhar, S., Panchal, J.P., Topp, E.M.(2015). Effect of hydrolytic degradation on the in vivo properties of monoclonal antibodies . AAPS Advances in the Pharmaceutical Sciences Series. 19. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 105-135.