プロフィール詳細

プロジェクトを作成

★★★★★

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☆☆☆☆☆

Smeeta S.に依頼

Nepal

Senior Biomedical Scientist (PhD) | Genomics, Epigenetics, Metabolomics & Microbiome Analysis Specialist | 17+ Years Exp

プロフィール概要

I’m a biomedical researcher with 17+ years of experience specializing in genomics, epigenetics (450K/850K), metabolomics, transcriptomics, and microbiome data interpretation. I help research teams, startups, and clinicians transform complex multi-omics datasets into clear, defensible, publication-ready insights. I’ve worked as a Senior Research Fellow in Singapore’s top medical schools and collaborated with major international consortia (UK, India, Singapore). My strength is rapid, rigorous interpretation, building logically sound narratives from raw data, and producing journal-quality scientific writing. Clients hire me when they need expertise, accuracy, and honest scientific judgment — not hand-holding or generic analysis. Services I Offer : Genomics & Epigenetics: 450K/850K methylation analysis • SNP/ROH analysis • QC • normalization • statistical modelling Metabolomics & Microbiome : Gut–metabolic links • multi-omics integration (metabolomics–transcriptomics–microbiome) Statistics & Data Processing : Regression, PCA, power calculations • data cleaning/QC • R, SPSS, STATA, Linux workflows Scientific Writing : Manuscripts, reviews, discussions • data interpretation • grant sections • scientific editing Study Design : Multi-omics study planning • protocols • audits of flawed analyses Why Clients Choose Me: 17+ yrs experience • multi-omics depth • strong scientific writing • excellent with messy datasets • international project coordination • direct, honest, accurate judgment Best Fit For : Research teams • clinicians • biotech startups • academic labs • anyone needing fast, precise, publication-ready science.

専門分野

• ☆ Microbiology
• ☆ Microbiome Research
• ☆ Biostatistics
• ☆ Molecular Biology
• ☆ Genetics
• ☆ Epigenetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Next Generation Sequencing (NGS)
• ☆ DNA Sequencing
• ☆ Gene Expression Analysis
• ☆ Genome Sequencing
• ☆ Exome Sequencing
• ☆ Cell Biology
• ☆ Cytogenetics
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Stem Cell Research
• ☆ Histology
• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Microscopy
• ☆ Cryosectioning
• ☆ Data Analysis
• ☆ Cluster Analysis
• ☆ Data Visualization
• ☆ Data Management
• ☆ Bioinformatics
• ☆ Gene & Protein Expression Analysis
• ☆ Blotting
• ☆ Cytometry
• ☆ SPSS
• ☆ Excel
• ☆ STATA
• ☆ R
• ☆ Technical & Scientific Writing
• ☆ Journal Selection
• ☆ Manuscript & Journal Article Writing
• ☆ Instructional Materials
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Science Communication
• ☆ Literature Review
• ☆ Systematic Literature Review
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing
• ☆ Course Content Writing
• ☆ Grant Writing

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Clinical Trial Documentation

Research Meta-Research, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization, Data Mining, Data Processing, Data Insights

職務経験

Research Fellow

Lee Kong Chian School of Medicine

6月 2021 - 現在

Assistant Professor

Dayananda Sagar University

8月 2017 - 3月 2021

Post Doctoral Fellow

Centre for Cellular and Molecular Biology

6月 2013 - 7月 2017

学歴

Ph.D. (School of Biological Sciences )

Nanyang Technological University

2月 2005 - 9月 2012

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Smeeta Shrestha, Ying Qi Goh, Guoxiang Cheam, Mingyue Yeong, Nidhi Bhayana, Abigail Thomson, Jingtao Zhang, Jia Xu, Patricia Conway, Yulan Wang (2025). Ex vivo study on prebiotic & choline combination to modulate gut bacteria, enhance choline bioavailability, and reduce TMA production . Microbiome Research Reports.

Smeeta Shrestha, Chew Leng Lim, Yu Zuan Or, Zoe Ong, Hwa Hwa Chung, Hirohito Hayashi, Shunsuke Chiba, Feng Lin, Valerie Chun Ling Lin (2020). Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism . eLife.

Guan, L., Yu, W.S., Shrestha, S., Or, Y.Z., Lufkin, T., Chan, Y.-S., Lin, V.C.L., Lim, L.W.(2020). TTC9A deficiency induces estradiol-mediated changes in hippocampus and amygdala neuroplasticity-related gene expressions in female mice . Brain Research Bulletin. 157. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 162-168.

Lim, C.L., Or, Y.Z., Ong, Z., Chung, H.H., Hayashi, H., Shrestha, S., Chiba, S., Feng, L., Lin, V.C.L.(2020). Estrogen exacerbates mammary involution through neutrophil dependent and independent mechanism . eLife. 9. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-65.

Clark, D.W., Okada, Y., Moore, K.H.S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C.L.K., Lin, K., Zhao, J.H., et al.(2019). Associations of autozygosity with a broad range of human phenotypes . Nature Communications. 10. (1).

Yadav, D.K., Shrestha, S., Lillycrop, K.A., Joglekar, C.V., Pan, H., Holbrook, J.D., Fall, C.H.D., Yajnik, C.S., Chandak, G.R.(2018). Vitamin B<inf>12</inf> supplementation influences methylation of genes associated with Type 2 diabetes and its intermediate traits . Epigenomics. 10. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 71-90.

James, P., Sajjadi, S., Tomar, A.S., Saffari, A., Fall, C.H.D., Prentice, A.M., Shrestha, S., Issarapu, P., Yadav, D.K., Kaur, L., et al.(2018). Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: A review of existing evidence in humans with specific focus on one-carbon metabolism . International Journal of Epidemiology. 47. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1910-1937.

Yadav, D.K., Shrestha, S., Dadhwal, G., Chandak, G.R.(2018). Identification and characterization of cis-regulatory elements 'insulator and repressor' in PPARD gene . Epigenomics. 10. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 613-627.

Chandak, G.R., Silver, M.J., Saffari, A., Lillycrop, K.A., Shrestha, S., Sahariah, S.A., Di Gravio, C., Goldberg, G., Tomar, A.S., Betts, M., et al.(2017). Protocol for the EMPHASIS study; Epigenetic mechanisms linking maternal pre-conceptional nutrition and children's health in India and Sub-Saharan Africa . BMC Nutrition. 3. (1).

Khot, V.V., Yadav, D.K., Shrestha, S., Kaur, L., Sundrani, D.P., Chavan-Gautam, P.M., Mehendale, S.S., Chandak, G.R., Joshi, S.R.(2017). Hypermethylated CpG sites in the MTR gene promoter in preterm placenta . Epigenomics. 9. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 985-996.

Joshi, P.K., Esko, T., Mattsson, H., Eklund, N., Gandin, I., Nutile, T., Jackson, A.U., Schurmann, C., Smith, A.V., Zhang, W., et al.(2015). Directional dominance on stature and cognition in diverse human populations . Nature. 523. (7561). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 459-462.

Tomar, A.S., Tallapragada, D.S., Nongmaithem, S.S., Shrestha, S., Yajnik, C.S., Chandak, G.R., Tomar, A.S., Tallapragada, D.S., Nongmaithem, S.S., Shrestha, S., et al.(2015). Intrauterine Programming of Diabetes and Adiposity . Current obesity reports. 4. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 418-428.

PREPRINT

Smeeta Shrestha, Maria Glymenaki, Sophie Curio, Mona El-Bahrawy, Yulan Wang, Nigel J. Gooderham, Nadia Guerra, Jia V. Li (2023). Tyramine promotes colon cancer risk and development by inducing DNA damage and inflammation .