プロフィール詳細

プロジェクトを作成

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Soumyajit M.に依頼

United Kingdom

Translational Immunology & Cancer Immunotherapy Scientist | Expert in Organoid–Immune Co-Culture & High-Content Imaging

プロフィール概要

Research scientist specialising in ex vivo evaluation of TCR and bispecific immunotherapies using patient-derived cancer organoid models. I design, troubleshoot, and optimise organoid–immune co-culture systems, assay protocols (flow cytometry, ELISA, IFN-γ ELISpot), and high-content imaging workflows (Incucyte, Cytation-5) for tumour-killing assessment across colorectal, pancreatic, and ovarian cancer models. Currently at the University of Birmingham (Dept. of Cancer and Genomic Sciences), with prior work spanning infectious disease vaccinology (DNA vaccine development) and T-cell immunology. Published in Oncogene, Journal of Infection, and Blood Cancer Journal. Available for protocol design, assay troubleshooting, SOP development, and lab operations advisory — remote or with scheduled on-site visits.

専門分野

• ☆ Biocatalysis
• ☆ Molecular Engineering
• ☆ Biopolymers
• ☆ Peptide Synthesis
• ☆ Physical Organic Chemistry
• ☆ Computational Biology
• ☆ Biostatistics
• ☆ Mathematical Biology
• ☆ Zoology
• ☆ Mammalian Biology
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Structural Biology
• ☆ Apoptosis
• ☆ Enzyme Activity Assays
• ☆ Binding Assays
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Microarrays
• ☆ Molecular Evolution
• ☆ Epigenetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Next Generation Sequencing (NGS)
• ☆ ATAC-Seq
• ☆ DNA Sequencing
• ☆ Synthetic Genomics
• ☆ Protein Sequencing
• ☆ Gene Expression Analysis
• ☆ Genome Sequencing
• ☆ Microinjection
• ☆ Mutagenesis
• ☆ Recombinant DNA
• ☆ RNA Synthesis
• ☆ RNA Sequencing
• ☆ DNA/Gene Synthesis
• ☆ Oligonucleotide Synthesis
• ☆ Plasmid DNA
• ☆ DNA Damage & Repair
• ☆ ChIP-Seq
• ☆ Kinases
• ☆ Monoclonal Antibody Production
• ☆ Molecular Ecology
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cytochemistry
• ☆ Cytogenetics
• ☆ Cell Signaling Pathways
• ☆ Membrane Biology
• ☆ Gene Regulation
• ☆ Stem Cell Research
• ☆ Biophysics
• ☆ Histology
• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Nanobiotechnology
• ☆ Biomedical Engineering
• ☆ Biomimetics
• ☆ Bioprinting
• ☆ Biomass & Bioenergy
• ☆ Microscopy
• ☆ Cryosectioning
• ☆ Light Microscopy
• ☆ Electron Microscopy
• ☆ Fluorescence Microscopy
• ☆ Biological Engineering
• ☆ Data Analysis
• ☆ Image Processing
• ☆ Computer Simulation/Computational Modeling
• ☆ Algorithm Design
• ☆ Predictive Modeling & Analytics
• ☆ Data Visualization
• ☆ Data Collection
• ☆ Artificial Intelligence
• ☆ Food Engineering
• ☆ Nutrition Science
• ☆ Food Microbiology
• ☆ Food Sensory Analysis
• ☆ Food Preservation
• ☆ Food Safety
• ☆ Food Processing
• ☆ Dairy Science
• ☆ Food Chemistry
• ☆ Food Testing
• ☆ Plant-Based Protein
• ☆ Vegetarian & Vegan Nutrition
• ☆ Food & Beverage Manufacturing
• ☆ Nutritional Analysis
• ☆ Biomarker Discovery
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Banking
• ☆ Cell Line Engineering
• ☆ Large Scale Cell Culture
• ☆ Cell Surface Receptors
• ☆ 3D Cell Culture
• ☆ Industrial Biotechnology
• ☆ Biosensors
• ☆ Bioenergy & Biofuels
• ☆ Agricultural Biotechnology
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Phylogenetics
• ☆ Population Genetics
• ☆ Tissue Engineering
• ☆ Artificial Organs
• ☆ Cytometry
• ☆ Cell Aging
• ☆ Library & Information Science
• ☆ Recipe Formulation
• ☆ Viticulture & Enology/Wine Production
• ☆ Medical Libraries
• ☆ Exercise & Fitness
• ☆ Physical Fitness
• ☆ Sports Science
• ☆ Exercise Physiology
• ☆ Athletic Training & Coaching
• ☆ Personal Training
• ☆ Men's Interest
• ☆ Celebrity News
• ☆ Fashion & Style
• ☆ Cooking
• ☆ Gardens & Gardening
• ☆ Sports Business
• ☆ Excel
• ☆ R
• ☆ Pharmacy
• ☆ Clinical Pharmacy
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Target Identification
• ☆ Phenotypic Assays
• ☆ High Content Screening/Imaging
• ☆ Drug Design
• ☆ Drug Development
• ☆ Biosafety Testing
• ☆ Microbiology Testing
• ☆ Drug Efficacy Testing
• ☆ Antibiotic Development
• ☆ Bioavailability
• ☆ Vaccine Development
• ☆ Pharmaceutical Manufacturing
• ☆ Bioprocess Development
• ☆ Small Molecule Manufacturing
• ☆ Biologic & Biosimilar Manufacturing
• ☆ In vitro Diagnostics
• ☆ In vitro Diagnostic Validation
• ☆ In vitro Diagnostic Design
• ☆ Biomarker Analysis
• ☆ Lab-on-a-Chip Devices
• ☆ Clinical Trials
• ☆ Clinical Trial Design
• ☆ Clinical Trials Data Analysis
• ☆ Allergy & Clinical Immunology
• ☆ Clinical Immunology
• ☆ HLA Typing/Tissue Typing
• ☆ Medical Genetics
• ☆ Immunogenetics
• ☆ Oncology
• ☆ Radiation Therapy
• ☆ Chemotherapy
• ☆ Precision Medicine
• ☆ Infectious Disease
• ☆ Viral Diseases
• ☆ Epstein-Barr Virus (EBV)
• ☆ Ebola
• ☆ COVID-19
• ☆ Antibiotic Resistance Research
• ☆ Health Informatics
• ☆ Immunotherapy
• ☆ Gene Therapy
• ☆ Medical Terminology
• ☆ Medical Sciences
• ☆ Connective Tissue
• ☆ Inflammation
• ☆ Vegan Products
• ☆ Product Evaluation
• ☆ Reverse Engineering
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Survey Design & Methodology
• ☆ Meta-Research
• ☆ Fact Checking
• ☆ Literature Search
• ☆ Gap Analysis
• ☆ Gray Literature Search
• ☆ Presentation Design
• ☆ Video Production
• ☆ Photography & Image Editing
• ☆ Process Design
• ☆ Audio Production
• ☆ Skills Training
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing
• ☆ Creative Writing
• ☆ Course Content Writing
• ☆ Grant Writing

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Medical Writing, Technical Writing, Creative Writing, Newswriting, General Proofreading & Editing

Research Market Research, Technology Scouting, Fact Checking, Gap Analysis, Scientific and Technical Research, Systematic Literature Review

Consulting Healthcare Consulting, Operations Consulting, Scientific and Technical Consulting, Regulatory Consulting

Data & AI Image Analysis, Data Visualization, Data Processing

Product Development Recipe Development, Product Evaluation, Concept Development, Reverse Engineering

職務経験

The University of Birmingham

- 現在

Senior Research Technician II

The University of Birmingham

11月 2025 - 現在

Reserach Technician

University of Birmingham

10月 2022 - 6月 2023

学歴

MSc in Biotechnology (Biotechnology)

University of Glasgow

9月 2021 - 9月 2022

B.Tech in Biotechnology (Biotechnology)

Techno India University

8月 2016 - 8月 2020

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Soumyajit Mallick, Sandra Margielewska-Davies, Wayne Croft, Hayden Pearce, Natalie To, Fouzia Zayou, Falguni Meghrajani, Jing Zhang, Claudia M. A. Pinna, Laura Bills, et al. (2026). IGF2BP3-mediated regulation of the RNA isoform and modification landscape in pancreatic cancer . Oncogene.

IGF2BP3-mediated regulation of the RNA isoform and modification landscape in pancreatic cancer @article{fe99695401294a18ac350059fc5bab82, title = "IGF2BP3-mediated regulation of the RNA isoform and modification landscape in pancreatic cancer", abstract = "The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing but clinical outcomes remain poor and new treatments are required. IGF2BP3 is an oncofetal m6A-reading RNA regulatory protein whose expression is commonly observed in PDAC and which may represent an important therapeutic target. IGF2BP3 protein is expressed in >95\% of primary tumours whilst RNA expression ranges from 3 to 3000-fold above normal epithelium. siRNA knockdown reveals IGF2BP3 to strongly support expression of gene programs related to DNA replication, cell cycle and apoptosis, TNF signalling and epithelial-mesenchymal transition. Direct sequencing of native RNA further reveals IGF2BP3-mediated enhancement of 863 RNA isoforms with suppression of 389 isoforms. m6A, m5C and pseudouridine (ψ) RNA modifications were seen in 97\% of transcripts within the PDAC transcriptome and enriched within MYC gene targets. IGF2BP3 regulated the pattern of RNA modification with a substantial impact on m5C modifications of miRNA and scRNA, and genes associated with regulation of TNF signalling. Knockdown of IGF2BP3 expression in primary tumour organoid cultures suppressed proliferation and elicited apoptosis, indicating a critical requirement for IGF2BP3 within malignant stem cells. These data show that IGF2BP3 is expressed consistently in PDAC, plays a dominant role in regulation of RNA splicing and modification, and supports cancer stem cell proliferation and survival. IGF2BP3 therefore occupies a critical position within the RNA regulon of PDAC and represents an important therapeutic target in this tumour of unmet need.", author = "Sandra Margielewska-Davies and Wayne Croft and Hayden Pearce and Natalie To and Fouzia Zayou and Falguni Meghrajani and Jing Zhang and Pinna, \{Claudia M A\} and Laura Bills and Beggs, \{Andrew D\} and Soumyajit Mallick and Powell-Brett, \{Sarah F\} and Rachel Brown and Jianmin Zuo and Roberts, \{Keith J.\} and Paul Moss", year = "2026", month = aug, day = "7", doi = "10.1038/s41388-026-03933-3", language = "English", journal = "Oncogene", issn = "0950-9232", publisher = "Nature Publishing Group", } . Oncogene.

Endemic penetrance of SARS-CoV-2 has impacted marginally on immunity to spike protein of human coronaviruses @article{5cc4b73764034476b134e59c2a1e5943, title = "Endemic penetrance of SARS-CoV-2 has impacted marginally on immunity to spike protein of human coronaviruses", abstract = "SARS-CoV-2 has emerged as the 5th endemic coronavirus and immunological cross protection between coronaviruses will influence their infectivity and clinical impact. We determined adaptive immunity against the spike protein of each human coronavirus during the course of the COVID-19 pandemic. A characteristic pattern of HCoV immunodominance, dominated by OC43 and 229E, was apparent prior to SARS-CoV-2 and was largely unaffected by SARS-CoV-2 infection, which itself elicited moderate antibody titre. Vaccination or hybrid immunity elicited supraphysiological levels of coronavirus-specific antibodies, only a proportion of which was cross-reactive with SARS-CoV-2 spike indicating substantial backboosting of HCoV-specific responses. SARS-CoV-2 vaccination focused antibody responses against the S1 domain of SARS-CoV-2 spike whilst T cell responses recognised peptides equivalently across S1 and S2. Coronavirus-specific T cells exhibited strong production of IFN-γ, IL-2 and CXCL8. In summary, the entry of SARS-CoV-2 into its ecological niche has impacted marginally on relative immunity against other human coronaviruses although vaccination provides a modest antibody increment which is unlikely to be maintained. Further, although SARS-CoV-2 vaccination elicits spike-specific adaptive immune responses that are focused against the S1 domain, thereby favouring neutralising antibodies, the natural history of HCoV immunity indicates that adaptive responses may transition towards S2 recognition across the life course.", author = "Tara Lancaster and Gokhan Tut and Panagiota Sylla and David Bone and Christopher Bentley and Eliska Spalkova and Azar Jadir and Rachel Bruton and Katie Spencer and Soumyajit Mallick and Ahmed Elzaidi and Siobhan Plass and Nayandeep Kaur and Megan Butler and Samuel Hulme and Dowell, \{Alexander C.\} and Maria Krutikov and Oliver Stirrup and Borscha Azmi and Andrew Hayward and Andrew Copas and Laura Shallcross and Paul Moss", year = "2026", month = feb, day = "9", doi = "10.1038/s42003-025-09474-x", language = "English", volume = "9", journal = "Communications Biology", issn = "2399-3642", publisher = "Nature Publishing Group", number = "1", } . Communications Biology.

Enhancement of Omicron-specific immune responses following bivalent COVID-19 booster vaccination in patients with chronic lymphocytic leukaemia @article{628c5c8405094a7ebe144b90b969fc17, title = "Enhancement of Omicron-specific immune responses following bivalent COVID-19 booster vaccination in patients with chronic lymphocytic leukaemia", keywords = "Humans, Leukemia, Lymphocytic, Chronic, B-Cell, COVID-19/prevention \& control", author = "Thomas Roberts and Grace Uwenedi and Rachel Bruton and Graham McIlroy and Sarah Damery and Panagiota Sylla and Nicola Logan and Sam Scott and May Lau and Ahmed Elzaidi and Siobhan Plass and Soumyajit Mallick and Katie Spencer and Christine Stephens and Christopher Bentley and Guy Pratt and Jianmin Zuo and Shankara Paneesha and Brian Willett and Paul Moss and Helen Parry", year = "2024", month = jan, day = "25", doi = "10.1038/s41408-023-00940-5", language = "English", volume = "14", journal = "Blood Cancer Journal", issn = "2044-5385", publisher = "Nature Publishing Group", number = "1", } . Blood Cancer Journal.

Soumyajit Mallick, Thomas Roberts, Grace Uwenedi, Rachel Bruton, Graham McIlroy, Sarah Damery, Panagiota Sylla, Nicola Logan, Sam Scott, May Lau, et al. (2024). Enhancement of Omicron-specific immune responses following bivalent COVID-19 booster vaccination in patients with chronic lymphocytic leukaemia . Blood Cancer Journal.

Soumyajit Mallick, Helen Parry, Rachel Bruton, Grace Uwenedi, Thomas Roberts, Panagiota Sylla, Jonathan Cook, Ahmed Elzaidi, May Lau, Tamsin Drury, et al. (2024). Robust generation of neutralising antibodies against Omicron variants following bivalent mRNA booster vaccine in elderly people aged >80 years . Journal of Infection.

Robust generation of neutralising antibodies against Omicron variants following bivalent mRNA booster vaccine in elderly people aged >80 years @article{e223088f8683401cabace006202f70ef, title = "Robust generation of neutralising antibodies against Omicron variants following bivalent mRNA booster vaccine in elderly people aged >80 years", author = "Helen Parry and Rachel Bruton and Grace Uwenedi and Thomas Roberts and Panagiota Sylla and Jonathan Cook and Ahmed Elzaidi and May Lau and Tamsin Drury and Alexander Bray and Soumyajit Mallick and Katie Spencer and Christopher Bentley and Graham McIlroy and Sam Scott and Nicola Logan and Jianmin Zuo and Brian Willett and Paul Moss", year = "2024", month = jan, doi = "10.1016/j.jinf.2023.08.014", language = "English", volume = "88", pages = "48--50", journal = "Journal of Infection", issn = "0163-4453", publisher = "Elsevier", number = "1", } . Journal of Infection.