プロフィール詳細

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★★★★★

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Dr. Sudipto G.に依頼

United States

Translational Immunologist with 15+ years experience in immuno-oncology therapeutic innovation

プロフィール概要

Distinguished translational immunology researcher with 10+ years of progressive leadership in oncology drug development at Johns Hopkins Cancer Center, currently serving as Fractional Chief Scientific Officer at OMAPiX, Inc. Demonstrated expertise in architecting preclinical-to-clinical transitions for immune checkpoint modulators, with direct experience advancing PVRIG, TIGIT, and CTLA-4 inhibitors from target validation through IND submission to Phase I clinical trials in ovarian and endometrial cancer. Former Assistant Professor with established independent research program, co-directing landmark clinical study (n=16 patients) quantifying radiation-associated immunodynamics in GBM (Glioblastoma multiforme) and securing multiple competitive awards including the Liz Tilberis Early Career Award and NCI SPORE Career Enhancement Program Award. Core technical capabilities span complex in vivo pharmacology (syngeneic/humanized tumor models, dose-finding studies), advanced molecular technologies (spatial transcriptomics, single-cell CITE-Seq, multi-color flow cytometry, proteomics), and biomarker-driven therapeutic development. Ph.D. in Biochemistry (Infectious Disease Immunology) with specialized expertise in tumor microenvironment analysis, macrophage/T cell/dendritic cell biology, and multi-omics platform integration. Proven track record leading cross-functional teams in academic and industry-collaborative settings, with sustained multi-year partnerships delivering strategic value across discovery, translational research, and clinical program support domains.

専門分野

• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Omics
• ☆ Proteomics
• ☆ RNA Sequencing
• ☆ Cell Biology
• ☆ Biomarker Discovery
• ☆ Cytometry
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Drug Development
• ☆ Preclinical Research
• ☆ Clinical Immunology
• ☆ Immunotherapy
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Technology Scouting
• ☆ Fact Checking
• ☆ Literature Search
• ☆ Technical & Scientific Writing
• ☆ Journal Selection
• ☆ Manuscript & Journal Article Writing
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Science Communication
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Scientific Proofreading & Editing
• ☆ Grant Writing

サービス

• Writing
• Research
• Consulting

Writing Medical Writing, Technical Writing, Audio Transcription, General Proofreading & Editing, Translation

Research User Research, Feasibility Study, Technology Scouting, Fact Checking, Gap Analysis, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

職務経験

Chief Scientific Officer (Fractional)

OMAPiX, Inc.

11月 2024 - 現在

Assistant Professor

Johns Hopkins University

3月 2019 - 8月 2024

Instructor

Johns Hopkins University

2月 2017 - 2月 2019

Research Associate

Johns Hopkins University

1月 2015 - 1月 2017

Research Associate

Johns Hopkins University

4月 2014 - 1月 2015

Post-doctoral fellow

Johns Hopkins University

1月 2010 - 3月 2014

学歴

PhD (Biochemistry)

University of Calcutta

1月 2004 - 10月 2009

Master of Science (Genetics and Plant Breeding)

University of Calcutta

8月 1999 - 9月 2001

Bachelor of Science (Botany)

University of Calcutta

8月 1996 - 7月 1999

認定資格

• 認定資格の詳細は未入力です。

出版物

PREPRINT

Sudipto Ganguly, Sarah Whelan, Eran Ophir, Maya F. Kotturi, Ofer Levy, Ling Leung, Ilan Vaknin, Sandeep Kumar, Liat Dassa, Kyle Hansen, et al. (2023). Data from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8⁺ T-cell Function .

Sudipto Ganguly, Sarah Whelan, Eran Ophir, Maya F. Kotturi, Ofer Levy, Ling Leung, Ilan Vaknin, Sandeep Kumar, Liat Dassa, Kyle Hansen, et al. (2023). Data from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8⁺ T-cell Function .

Sudipto Ganguly, Sarah Whelan, Eran Ophir, Maya F. Kotturi, Ofer Levy, Ling Leung, Ilan Vaknin, Sandeep Kumar, Liat Dassa, Kyle Hansen, et al. (2023). Supplementary Figure Legends from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8⁺ T-cell Function .

Sudipto Ganguly, Sarah Whelan, Eran Ophir, Maya F. Kotturi, Ofer Levy, Ling Leung, Ilan Vaknin, Sandeep Kumar, Liat Dassa, Kyle Hansen, et al. (2023). Supplementary Figure Legends from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8⁺ T-cell Function .

Sudipto Ganguly, Sarah Whelan, Eran Ophir, Maya F. Kotturi, Ofer Levy, Ling Leung, Ilan Vaknin, Sandeep Kumar, Liat Dassa, Kyle Hansen, et al. (2023). Supplementary Figures and Tables from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8⁺ T-cell Function .

Sudipto Ganguly, Sarah Whelan, Eran Ophir, Maya F. Kotturi, Ofer Levy, Ling Leung, Ilan Vaknin, Sandeep Kumar, Liat Dassa, Kyle Hansen, et al. (2023). Supplementary Figures and Tables from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8⁺ T-cell Function .

Sudipto Ganguly, Sergey Nemzer, Niv Sabath, Assaf Wool, Zoya Alteber, Hirofumi Ando, Amanda Nickles-Fader, Tian-Li Wang, Ie-Ming Shih, Drew M. Pardoll, et al. (2022). Gene model correction for PVRIG in single cell and bulk sequencing data enables accurate detection and study of its functional relevance .

JOURNAL ARTICLE

Sudipto Ganguly, Zoya Alteber, Maya F. Kotturi, Sarah Whelan, Emmanuel Weyl, Drew M. Pardoll, John Hunter, Eran Ophir (2021). Therapeutic Targeting of Checkpoint Receptors within the DNAM1 Axis . Cancer Discovery.

(2020). High-Dimensional Cytometry (ExCYT) and Mass Spectrometry of myeloid infiltrate in clinically localized clear cell Renal Cell Carcinoma identifies novel potential myeloid targets for immunotherapy . Molecular & Cellular Proteomics.

Sudipto Ganguly, Mark Yarchoan, Won Jin Ho, Aditya Mohan, Yajas Shah, Teena Vithayathil, James Leatherman, Lauren Dennison, Neeha Zaidi, Skylar Woolman, et al. (2020). Effects of B cell–activating factor on tumor immunity . JCI Insight.

(2020). Transcriptional profiling of tumor associated macrophages in human renal cell carcinoma reveals significant heterogeneity and opportunity for immunomodulation . American journal of clinical and experimental urology.

Sudipto Ganguly, Sven D. Sommerfeld, Christopher Cherry, Remi M. Schwab, Liam Chung, David R. Maestas, Jr., Philippe Laffont, Julie E. Stein, Ada Tam, Franck Housseau, et al.(2019). Interleukin-36γ–producing macrophages drive IL-17–mediated fibrosis . Science Immunology. 4. (40). American Association for the Advancement of Science ({AAAS})

Sudipto Ganguly, Sarah Whelan, Eran Ophir, Maya F. Kotturi, Ofer Levy, Ling Leung, Ilan Vaknin, Sandeep Kumar, Liat Dassa, Kyle Hansen, et al. (2019). PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function . Cancer Immunology Research.

Sudipto Ganguly, Sarah Whelan, Eran Ophir, Maya F. Kotturi, Ofer Levy, Ling Leung, Ilan Vaknin, Sandeep Kumar, Liat Dassa, Kyle Hansen, et al.(2019). PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function . Cancer Immunology Research. 7. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 257--268. American Association for Cancer Research ({AACR})

Sudipto Ganguly, Kaitlyn Sadtler, Matthew T. Wolf, Christopher A. Moad, Liam Chung, Shoumyo Majumdar, Franck Housseau, Drew M. Pardoll, Jennifer H. Elisseeff(2019). Divergent immune responses to synthetic and biological scaffolds . Biomaterials. 192. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 405--415. Elsevier {BV}

Sudipto Ganguly, Benjamin Murter, Xiaoyu Pan, Eran Ophir, Zoya Alteber, Meir Azulay, Rupashree Sen, Ofer Levy, Liat Dassa, Ilan Vaknin, et al.(2019). Mouse PVRIG Has CD8+ T Cell–Specific Coinhibitory Functions and Dampens Antitumor Immunity . Cancer Immunology Research. 7. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 244--256. American Association for Cancer Research ({AACR})

Sudipto Ganguly, Matthew T. Wolf, Tony L. Wang, Christopher W. Anderson, Kaitlyn Sadtler, Radhika Narain, Christopher Cherry, Alexis J. Parrillo, Benjamin V. Park, Guannan Wang, et al.(2019). A biologic scaffold–associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy . Science Translational Medicine. 11. (477). American Association for the Advancement of Science ({AAAS})

Sudipto Ganguly, John-William Sidhom, Debebe Theodros, Benjamin Murter, Jelani C. Zarif, Drew M. Pardoll, Alexander Baras(2019). ExCYT: A Graphical User Interface for Streamlining Analysis of High-Dimensional Cytometry Data . Journal of Visualized Experiments. (143). {MyJove} Corporation

Sudipto Ganguly, Liam Chung, Erik Thiele Orberg, Abby L. Geis, June L. Chan, Kai Fu, Christina E. DeStefano Shields, Christine M. Dejea, Payam Fathi, Jie Chen, et al.(2018). Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells . Cell Host & Microbe. 23. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 421. Elsevier {BV}

Sudipto Ganguly, Tomas Garzon-Muvdi, Debebe Theodros, Andrew S. Luksik, Russell Maxwell, Eileen Kim, Christopher M. Jackson, Zineb Belcaid, Betty Tyler, Henry Brem, et al.(2018). Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma . Oncotarget. 9. (29). Impact Journals, {LLC}

Sudipto Ganguly, Anna F. Piotrowski, Thomas R. Nirschl, Esteban Velarde, Lee Blosser, Kathleen H. Burns, Leo Luznik, John Wong, Charles G. Drake, Stuart A. Grossman(2018). Systemic depletion of lymphocytes following focal radiation to the brain in a murine model . OncoImmunology. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e1445951. Informa {UK} Limited

Thiele Orberg E, Fan H, Tam AJ, Dejea CM, Destefano Shields CE, Wu S, Chung L, Finard BB, Wu X, Fathi P, et al.(2017). The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis . Mucosal immunology.

E Chang, S Ganguly, T Rajkhowa, C D Gocke, M Levis, H Konig(2016). The combination of FLT3 and DNA methyltransferase inhibition is synergistically cytotoxic to FLT3/ITD acute myeloid leukemia cells . Leukemia. 30. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1025--1032. Springer Science and Business Media {LLC}

Housseau F, Wu S, Wick EC, Fan H, Wu X, Llosa NJ, Smith KN, Tam A, Ganguly S, Wanyiri JW, Iyadorai T, Malik AA, Roslani AC, Vadivelu JS, Van Meerbeke S, Huso DL, Pardoll DM, Sears CL, Cancer research, 2016 .

Sudipto Ganguly, Jeffrey M. Dodd-o, Ante Vulic, Angela Panoskaltsis-Mortari, John F. McDyer, Leo Luznik(2016). Induction of Major Histocompatibility Complex-mismatched Mouse Lung Allograft Acceptance With Combined Donor Bone Marrow . Transplantation. 100. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e140--e146. Ovid Technologies (Wolters Kluwer Health)

Sudipto Ganguly, Salvador Alonso, Meng Su, Jace W. Jones, Maureen A. Kane, Richard J. Jones, Gabriel Ghiaur(2015). Human bone marrow niche chemoprotection mediated by cytochrome P450 enzymes . Oncotarget. 6. (17). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 14905--14912. Impact Journals, {LLC}

Sudipto Ganguly, Elizabeth A. Lendermon, Jeffrey M. Dodd-o, Tiffany A. Coon, Hannah L. Miller, Iulia Popescu, Christopher P. O'Donnell, Nayra Cardenes, Melanie Levine, Mauricio Rojas, et al.(2015). CD8 + IL-17 + T Cells Mediate Neutrophilic Airway Obliteration in T-bet–Deficient Mouse Lung Allograft Recipients . Am J Respir Cell Mol Biol. 52. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 622--633. American Thoracic Society

Alonso S, Su M, Jones JW, Ganguly S, Kane MA, Jones RJ, Ghiaur G, Oncotarget, 2015 .

Sudipto Ganguly, Christopher G Kanakry, Leo Luznik(2015). Situational aldehyde dehydrogenase expression by regulatory T cells may explain the contextual duality of cyclophosphamide as both a pro-inflammatory and tolerogenic agent . OncoImmunology. 4. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e974393. Informa {UK} Limited

Auletta JJ, Eid SK, Wuttisarnwattana P, Silva I, Metheny L, Keller MD, Guardia-Wolff R, Liu C, Wang F, Bowen T, Lee Z, Solchaga LA, Ganguly S, Tyler M, Wilson DL, Cooke KR, Stem cells (Dayton, Ohio), 2015, vol. 33, no. 2, pp. 601-614 .

Ganguly S, Ross DB, Panoskaltsis-Mortari A, Kanakry CG, Blazar BR, Levy RB, Luznik L, Blood, 2014 .

Kanakry CG, Ganguly S, Zahurak M, Bolaños-Meade J, Thoburn C, Perkins B, Fuchs EJ, Jones RJ, Hess AD, Luznik L, Science translational medicine, 2013, vol. 5, no. 211, pp. 211ra157 .

Sen R, Saha P, Sarkar A, Ganguly S, Chatterjee M, Free radical research, 2010, vol. 44, no. 11, pp. 1289-1295 .

Ganguly S, Das NK, Barbhuiya JN, Chatterjee M, International journal of dermatology, 2010, vol. 49, no. 8, pp. 921-931 .

Sen R, Ganguly S, Saha P, Chatterjee M, International journal of antimicrobial agents, 2010, vol. 36, no. 1, pp. 43-49 .

Ganguly S, Mukhopadhyay D, Das NK, Chaduvula M, Sadhu S, Chatterjee U, Rahman M, Goswami RP, Guha SK, Modak D, Mallik S, Gonju D, Pramanik N, Barbhuiya JN, Saha B, Chatterjee M, The Journal of investigative dermatology, 2010, vol. 130, no. 4, pp. 1013-1022 .

Bandyopadhyay S, Ganguly S, Mandal G, Sen R, Saha P, Ghosh MK, Sarkar M, Chatterjee M, Research in veterinary science, 2009, vol. 87, no. 1, pp. 85-90 .

Mandal S, Maharjan M, Ganguly S, Chatterjee M, Singh S, Buckner FS, Madhubala R, Indian journal of experimental biology, 2009, vol. 47, no. 6, pp. 475-479 .

Chatterjee S, Mookerjee A, Basu JM, Chakraborty P, Ganguly A, Adhikary A, Mukhopadhyay D, Ganguli S, Banerjee R, Ashraf M, Biswas J, Das PK, Sa G, Chatterjee M, Das T, Choudhuri SK, PloS one, 2009, vol. 4, no. 9, pp. e7048 .

Sarkar D, Saha P, Gamre S, Bhattacharjee S, Hariharan C, Ganguly S, Sen R, Mandal G, Chattopadhyay S, Majumdar S, Chatterjee M, International immunopharmacology, 2008, vol. 8, no. 9, pp. 1264-1271 .

Ganguly S, Das NK, Panja M, Pal S, Modak D, Rahaman M, Mallik S, Guha SK, Pramanik N, Goswami R, Barbhuiya JN, Saha B, Chatterjee M, The Journal of infectious diseases, 2008, vol. 197, no. 12, pp. 1762-1771 .

Chakraborty PK, Mustafi SB, Ganguly S, Chatterjee M, Raha S, Cancer science, 2008, vol. 99, no. 6, pp. 1109-1116 .

R Biswas, P Ghosh, N Banerjee, J. Das, T Sau, A Banerjee, S Roy, S Ganguly, M Chatterjee, A Mukherjee, et al.(2008). Analysis of T-cell proliferation and cytokine secretion in the individuals exposed to arsenic . Human & Experimental Toxicology. 27. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 381--386. {SAGE} Publications

Sarkar A, Sen R, Saha P, Ganguly S, Mandal G, Chatterjee M, Parasitology research, 2008, vol. 102, no. 6, pp. 1249-1255 .

Banerjee N, Banerjee M, Ganguly S, Bandyopadhyay S, Das JK, Bandyopadhay A, Chatterjee M, Giri AK, Toxicology, 2008, vol. 246, no. 2-3, pp. 101-111 .

Sen R, Bandyopadhyay S, Dutta A, Mandal G, Ganguly S, Saha P, Chatterjee M, Journal of medical microbiology, 2007, vol. 56, no. Pt 9, pp. 1213-1218 .

Ganguly S, Mula S, Chattopadhyay S, Chatterjee M, The Journal of pharmacy and pharmacology, 2007, vol. 59, no. 5, pp. 711-718 .

Ganguly S, Bandyopadhyay S, Sarkar A, Chatterjee M, Journal of microbiological methods, 2006, vol. 66, no. 1, pp. 79-86 .