プロフィール詳細

プロジェクトを作成

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Dr. Sumana G.に依頼

India

15+ years experience in medicinal chemistry. Involved in AI-based new drug design to lead optimisation till IND stage.

プロフィール概要

Fifteen+ years experience in medicinal chemistry, organic chemistry, drug discovery, and patent analysis. Strong background in strategic planning and executing drug discovery project starting from in silico design of new structural scaffolds, AI platform to predict ADME and toxicity profile, Hit identification, Hit to Lead optimisation till pre-clinical development. 10 years experience in new antibiotic drug discovery program and published scientific findings in many peer-reviewed journals (https://pubmed.ncbi.nlm.nih.gov/xxxxxxxx/) and patents (fifteen granted global patent applications in the areas of Medicinal Chemistry) 2.5 years experience in new drug discovery in oncology and precision medicine. Highly creative and experienced in leading and motivating team with high integrity. Energetic leader with proven skills in delivering project within stipulated time.

専門分野

• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Medicinal Chemistry
• ☆ Drug Design
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Antibiotic Development

サービス

• Writing
• Research

Writing Medical Writing, Technical Writing, Creative Writing

Research User Research

職務経験

Consultant

Capulus Therapeutics LLC (SAN FRANCISCO, USA)

8月 2020 - 現在

Head of Discovery

Capulus Therapeutics LLC

7月 2020 - 現在

Associate Director

Vyome Biosciences (India)

8月 2010 - 6月 2020

学歴

Post doctoral Associate (DNA-Small molecule Lab)

Université Joseph Fourier

1月 2007 - 6月 2008

PhD (Organic Chemistry)

Indian Institute of Science Bangalore

1月 2002 - 12月 2006

PhD (Chemistry)

Indian Institute of Science, Bangalore

1月 2002 - 12月 2006

認定資格

• PhD

  IISc Bangalore

  12月 2006 - 現在

出版物

JOURNAL ARTICLE

Ghosh S, Sinha M, Samanta R, Sadhasivam S, Bhattacharyya A, Nandy A, Saini S, Tandon N, Singh H, Gupta S, et al. (2022). A potent antibiotic-loaded bone-cement implant against staphylococcal bone infections . Nature biomedical engineering.

Sumana Ghosh, Anamika Bhattacharyya, Mau Sinha, Himanshi Singh, Ranjeet Singh Patel, Kabir Sardana, Shamik Ghosh, Shiladitya Sengupta(2020). Mechanistic Insight Into the Antifungal Effects of a Fatty Acid Derivative Against Drug-Resistant Fungal Infections . Frontiers in Microbiology. 11. Frontiers Media {SA}

Sumana Ghosh, Mau Sinha, Anamika Bhattacharyya, Suresh Sadhasivam, Jayasundarnaidu Megha, Sreedhar Reddy, Swamini Saini, Himanshi Singh, Deepak Kumar, Simar Preet Kaur, et al.(2018). A Rationally Designed Multifunctional Antibiotic for the Treatment of Drug-Resistant Acne . Journal of Investigative Dermatology. 138. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1400--1408. Elsevier {BV}

Sumana Ghosh, Muslum Yildiz, Jeffrey A. Bell, Woody Sherman, Jeanne A. Hardy(2013). Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus . ACS Chemical Biology. 8. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2744--2752. American Chemical Society ({ACS})

Sumana Ghosh, Gustavo E. López, Inara Colón-Díaz, Anthony Cruz, Samantha B. Nicholls, Usha Viswanathan, Jeanne A. Hardy, Scott M. Auerbach(2012). Modeling Nonaqueous Proton Wires Built from Helical Peptides: Biased Proton Transfer Driven by Helical Dipoles . The Journal of Physical Chemistry A. 116. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1283--1288. American Chemical Society ({ACS})

Sumana Ghosh, Kristen L. Huber, Jeanne A. Hardy(2012). Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface . Biopolymers. 98. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 451--465. Wiley

Sumana Ghosh, Nunzio Tuccitto, Nicoletta Giamblanco, Valentina Spampinato, Pierre Labbé, Pascal Dumy, Silvio Quici, Giovanni Marletta, Eric Defrancq, Antonino Licciardello(2011). Controlled Density Patterning of Tolylterpyridine-Tagged Oligonucleotides . Langmuir. 27. (14). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 8595--8599. American Chemical Society ({ACS})

Sumana Ghosh, Eric Defrancq(2010). Metal-Complex/DNA Conjugates: A Versatile Building Block for DNA Nanoarrays . Chemistry - A European Journal. 16. (43). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 12780--12787. Wiley

Sumana Ghosh, Stéphanie Deroo, Stéphane Le Gac, Mathilde Villien, Pascal Gerbaux, Eric Defrancq, Cécile Moucheron, Pascal Dumy, Andrée Kirsch‐De Mesmaeker(2009). Oligonucleotide Duplexes with Tethered Photoreactive Ruthenium(II) Complexes: Influence of the Ligands and Their Linker on the Photoinduced Electron Transfer and Crosslinking Processes of the Two Strands . European Journal of Inorganic Chemistry. 2009. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 524--532. Wiley

Sumana Ghosh, Isabelle Pignot-Paintrand, Pascal Dumy, Eric Defrancq(2009). Design and synthesis of novel hybrid metal complex–DNA conjugates: key building blocks for multimetallic linear DNA nanoarrays . Organic & Biomolecular Chemistry. 7. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2729. Royal Society of Chemistry ({RSC})

Sumana Ghosh, Dandamudi Usharani, Ananya Paul, Susmita De, Eluvathingal D. Jemmis, Santanu Bhattacharya(2008). Design, Synthesis, and DNA Binding Properties of Photoisomerizable Azobenzene−Distamycin Conjugates: An Experimental and Computational Study . Bioconjugate Chemistry. 19. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2332--2345. American Chemical Society ({ACS})

Sumana Ghosh, Dandamudi Usharani, Susmita De, Eluvathingal D. Jemmis, Santanu Bhattacharya(2008). Photophysical and Duplex-DNA-Binding Properties of Distamycin Dimers Based on 4,4′- and 2,2′-Dialkoxyazobenzenes as the Core . Chemistry - An Asian Journal. 3. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1949--1961. Wiley

Sumana Ghosh, Leslie Herman, Eric Defrancq, Andrée Kirsch-De Mesmaekera(2008). Ru(II) complexes and light: molecular tools for biomolecules . Journal of Physical Organic Chemistry. 21. (7-8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 670--681. Wiley

Sumana Ghosh, Eric Defrancq, Jean H. Lhomme, Pascal Dumy, Santanu Bhattacharya(2004). Efficient Conjugation and Characterization of Distamycin-Based Peptides with Selected Oligonucleotide Stretches . Bioconjugate Chemistry. 15. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 520--529. American Chemical Society ({ACS})

PATENT

Sumana Ghosh US20160058775.

Sumana Ghosh US2020140460.

Sumana Ghosh US10232047.

Sumana Ghosh WO2018042367.

Sumana Ghosh US201831831.

Sumana Ghosh US9907812.