プロフィール詳細

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Dr. Swetha M.に依頼

United States

Subject matter expert in Molecular aspects of Neurodegeneration and aging - Project Management - Due Diligence

プロフィール概要

Meet Dr. Swetha Mohan Ph.D., a leading expert in the field of neurological disorders and aging. With over 15 years of experience in the field, she has a deep understanding of disease pathogenesis. She has handled patient derived samples and induced pluripotent stem cells (iPSCs), created in vitro models of disease and probed them to identify novel targets for drug discovery. During her Postdoctoral work at the UCSF-MAC, Dr. Mohan's research focussed on molecular aspects of disease in patients with Frontotemporal Dementia and Alzheimer's Disease with a focus on lysosomal biology and UPR stress. She worked with patient-derived cells carrying relevant disease mutations. She used a variety of cell biology, molecular biology, biochemistry and microscopy-based techniques and assays to answer questions. She developed a novel in vitro lysosomal enzyme assay to determine disease protein cleavage. ​Swetha's Doctoral research at Simon Fraser University was focussed on sensory changes during aging using Caenorhabditis elegans as model system focusing on neuronal primary cilia which is also implicated in several neurodegenerative diseases. With a strong base in basic science, genetics and cell biology ​Swetha was an integral part of the Neuroscience team in a Bay Area-based start up company where she worked on multiple projects successfully helping with Go/No Go decisions for the program. She is an excellent team player and made significant independent contributions to the program. ​As an independent consultant, Swetha brings a unique skillset, enormous passion and scientific rigor to all her projects which makes her an excellent asset to any biotech or pharmaceutical company that is looking to advance their programs, gain partnership and bring new solutions.

専門分野

• ☆ Biochemistry
• ☆ Biochemical Assays
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Enzyme Activity Assays
• ☆ Molecular Biology
• ☆ PCR
• ☆ Next Generation Sequencing (NGS)
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Neuroscience
• ☆ Molecular Neuroscience
• ☆ Neurobiology
• ☆ Biotechnology & Bioengineering
• ☆ Microscopy
• ☆ Fluorescence Microscopy
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Blotting
• ☆ Cell Aging

サービス

• Writing
• Research
• Consulting

Writing Technical Writing, General Proofreading & Editing

Research Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

職務経験

Independent Consultant

Multiple clients

4月 2021 - 現在

Postdoctoral Fellow

University of California San Francisco

10月 2015 - 現在

Scientific /Technical writer

Stellate Communications

8月 2022 - 4月 2023

Scientist II

Engine Biosciences

4月 2019 - 4月 2021

Postdoctoral Researcher

UCSF memory and aging center

10月 2015 - 4月 2019

Postdoctoral Fellow

Stanford University

11月 2014 - 3月 2015

Postdoctoral Fellow

Simon Fraser University

10月 2013 - 10月 2014

学歴

Doctor of Philosophy

Simon Fraser University

9月 2007 - 6月 2014

PhD (Molecular Biology and Biochemistry)

Simon Fraser University

9月 2007 - 9月 2013

認定資格

• teaching course

  Simon Fraser University

  1月 2013 - 現在

出版物

JOURNAL ARTICLE

Swetha Mohan, Paul J. Sampognaro, Andrea R. Argouarch, Jason C. Maynard, Mackenzie Welch, Anand Patwardhan, Emma C. Courtney, Jiasheng Zhang, Amanda Mason, Kathy H. Li, et al. (2021). Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration . Molecular Neurodegeneration.

Swetha Mohan, Victor L Jensen, Nils J Lambacher, Chunmei Li, Corey L Williams, Peter N Inglis, Bradley K Yoder, Oliver Blacque, Michel Leroux (2018). Role for intraflagellar transport in building a functional transition zone . EMBO reports.

Swetha Mohan, Guruprasada Reddy Sure, Anusheela Chatterjee, Nikhil Mishra, Vidur Sabharwal, Swathi Devireddy, Anjali Awasthi, Sandhya P. Koushika (2018). UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport . Scientific Reports.

Swetha Mohan, Tiffany Timbers, Stephanie J. Garland, Stephane Flibotte, Mark Edgley, Quintin Muncaster, Vinci Au, Erica Li-Leger, Federico Rosell, Jerry Cai, et al. (2016). Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT) . PLOS Genetics.

Swetha Mohan, Victor L Jensen, Chunmei Li, Rachel V Bowie, Lara Clarke, Oliver E Blacque, Michel R Leroux (2015). Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (<scp>CIZE</scp>) that compartmentalises ciliary signalling proteins and controls <scp>PIP</scp>₂ ciliary abundance . The EMBO Journal.

Swetha Mohan, Tiffany&#160;A. Timbers, Julie Kennedy, Oliver&#160;E. Blacque, Michel&#160;R. Leroux (2013). Striated Rootlet and Nonfilamentous Forms of Rootletin Maintain Ciliary Function . Current Biology.

Swetha Mohan, Prasad Phirke, Evgeni Efimenko, Jan Burghoorn, Filip Crona, Mathieu W. Bakhoum, Maria Trieb, Kim Schuske, Erik M. Jorgensen, Brian P. Piasecki, et al. (2011). Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport . Developmental Biology.

Swetha Mohan, Corey L. Williams, Chunmei Li, Katarzyna Kida, Peter N. Inglis, Lucie Semenec, Nathan J. Bialas, Rachel M. Stupay, Nansheng Chen, Oliver E. Blacque, et al. (2011). MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis . Journal of Cell Biology.