プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Taufeeque A.に依頼

United States

Expert Cancer Research Scientist | Drug Development & ROS-Activated Prodrug Specialist

プロフィール概要

Ph.D. biochemist and Principal Investigator with 5+ years of hands-on research experience in cancer therapeutics and translational medicine. Expertise centers on developing novel, tumor-selective therapies, particularly ROS-activated prodrugs (e.g., phenylboronic acid nitrogen mustards) for cancers like triple-negative breast cancer (TNBC). Proven track record in designing and executing in vitro and in vivo studies (cell culture, xenograft models, flow cytometry, Western blot, PCR, ELISA) to evaluate drug safety, efficacy, and mechanism of action. Successfully filed patents, secured NIH/commercialization grants, and published in peer-reviewed journals (e.g., ACS Pharmacology & Translational Science, Cancers). As founder/CEO of SynXT Therapeutics, I bring experience in project leadership, commercialization strategy, and interdisciplinary collaboration. Available for freelance projects in medical/scientific writing, data analysis, experimental design, grant writing, and consulting on cancer research, drug development, and molecular biology.

専門分野

• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Apoptosis
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Antioxidants
• ☆ Enzyme Activity Assays
• ☆ Binding Assays
• ☆ Molecular Biology
• ☆ Microarrays
• ☆ Epigenetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Gene Expression Analysis
• ☆ Recombinant DNA
• ☆ DNA Damage & Repair
• ☆ Biomarker Discovery
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical Pharmacology
• ☆ In vivo Preclinical Toxicology
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Carcinogenesis

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Medical Writing

Research User Research, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization, Data Cleaning, Data Processing, Data Insights

職務経験

CEO

SynXT Therapeutics Inc.,

1月 2024 - 現在

Graduate Research & Teaching Assistant

University of Wisconsin-Milwaukee

1月 2019 - 8月 2024

Manufacturing Engineer

GE Healthcare

11月 2016 - 12月 2018

学歴

PhD. Chemistry (Chemistry and Biochemistry)

University of Wisconsin–Milwaukee

1月 2019 - 8月 2024

B. Sc. Biomolecular Engineering (Biomolecular Engineering)

Milwaukee School of Engineering

11月 2011 - 5月 2015

認定資格

• Six Sigma Green Belt Certification

  Milwaukee School of Engineering

  5月 2015 - 現在

出版物

JOURNAL ARTICLE

Taufeeque Ali, Eron Saxon, Xiaohua Peng (2024). Hydrogen peroxide responsive theranostics for cancer-selective activation of DNA alkylators and real-time fluorescence monitoring in living cells . European Journal of Medicinal Chemistry.

Taufeeque Ali, Daniel Li, Thilini Nimasha Fernando Ponnamperumage, Alexis Kimberly Peterson, Jatin Pandey, Kulsum Fatima, John Brzezinski, Julia Anna Rose Jakusz, Hanlun Gao, Gilbert Edward Koelsch, et al. (2024). Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment . Cancers.

Ali, T., Li, D., Ponnamperumage, T.N.F., Peterson, A.K., Pandey, J., Fatima, K., Brzezinski, J., Jakusz, J.A.R., Gao, H., Koelsch, G.E., et al.(2024). Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment . Cancers. 16. (12).

Saxon, E., Ali, T., Peng, X.(2024). Hydrogen peroxide responsive theranostics for cancer-selective activation of DNA alkylators and real-time fluorescence monitoring in living cells . European Journal of Medicinal Chemistry. 276.

Taufeeque Ali, Qi Zhang, Zechao Lin, Xiaohua Peng (2023). Development of 4,4′-dibromobinaphthalene analogues with potent photo-inducible DNA cross-linking capability and cytotoxicity towards breast MDA-MB 468 cancer cells . Bioorganic Chemistry.

Zhang, Q., Ali, T., Lin, Z., Peng, X.(2023). Development of 4,4′-dibromobinaphthalene analogues with potent photo-inducible DNA cross-linking capability and cytotoxicity towards breast MDA-MB 468 cancer cells . Bioorganic Chemistry. 140.

Taufeeque Ali, Heli Fan, Muhammad Asad Uz Zaman, Wenbing Chen, Anahit Campbell, Qi Zhang, Nurul Islam Setu, Eron Saxon, Nicolas M. Zahn, Anna M. Benko, et al. (2021). Assessment of Phenylboronic Acid Nitrogen Mustards as Potent and Selective Drug Candidates for Triple-Negative Breast Cancer . ACS Pharmacology & Translational Science.

Fan, H., Zaman, M.A.U., Chen, W., Ali, T., Campbell, A., Zhang, Q., Setu, N.I., Saxon, E., Zahn, N.M., Benko, A.M., et al.(2021). Assessment of Phenylboronic Acid Nitrogen Mustards as Potent and Selective Drug Candidates for Triple-Negative Breast Cancer . ACS Pharmacology and Translational Science. 4. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 687-702.

PREPRINT

Taufeeque Ali, Daniel Li, Thilini Nimasha Fernando Ponnamperumage, Alexis Kimberly Peterson, Jatin Pandey, Kulsum Fatima, John Brzezinski, Julia Anna Rose Jakusz, Hanlun Gao, Gilbert Edward Koelsch, et al. (2024). Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment .

Taufeeque Ali, Qi Zhang, Zechao Lin, Xiaohua Peng (2023). Development of 4,4’-Dibromobinaphthalene Analogues with Potent Photo-Inducible DNA Cross-Linking Capability and Cytotoxicity Towards Cancer Cells .

OTHER

Zhang, Q., Ali, T., Lin, Z., Peng, X.(2023). Development of 4,4’-Dibromobinaphthalene Analogues with Potent Photo-Inducible DNA Cross-Linking Capability and Cytotoxicity Towards Cancer Cells . SSRN.