プロフィール詳細

プロジェクトを作成

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Dr. Tomas B.に依頼

Belgium

Senior Biotech Consultant | Viral Vectors, RNA Therapeutics & Translational R&D Expert

プロフィール概要

I am a senior molecular biologist and biotech consultant with over 20 years of experience in virology, epigenetics, gene therapy, RNA biology, and translational research. I have designed and led the development of multiple viral and RNA-based therapeutic platforms, including self-amplifying RNA systems and non-integrative viral vectors for targeted delivery. My expertise spans viral vector engineering (Paramyxoviruses, VSV, lentiviral, adenoviral), RNA therapeutics, CAR-T/NK cell development, and GMP/GLP-compliant R&D. I combine deep technical knowledge with hands-on experience in grant writing, intellectual property, experimental design, and strategic planning. My work has contributed to >€1M in successful funding, peer-reviewed publications, and translational project execution. I am available for freelance consulting in scientific and translational strategy, project review, proposal development, and viral platform optimization.

専門分野

• ★ Molecular Virology
• ★ Gene Delivery
• ☆ Retrovirology
• ☆ Adenoviruses
• ☆ Molecular Biology
• ☆ Epigenetics
• ☆ Recombinant DNA
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Industrial Biotechnology
• ☆ Gene Synthesis
• ☆ Genetic Engineering
• ☆ Gene Editing/CRISPR
• ☆ Antibody Engineering
• ☆ Immunotherapy
• ☆ Gene Therapy
• ☆ Technical & Scientific Writing
• ☆ Manuscript & Journal Article Writing
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing, Business & Legal Writing, Copywriting, General Proofreading & Editing

Research Feasibility Study, Technology Scouting, Scientific and Technical Research, Systematic Literature Review

Consulting Business Strategy Consulting, Go-to-Market Strategy Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization, Text Mining & Analytics, Data Insights

Product Development Formulation, Product Validation, Concept Development, Prototyping

職務経験

Biotech Consultant and Editor

TBos Consulting

5月 2025 - 現在

Founder / CSO

Questa Bio SRL

8月 2024 - 4月 2025

Founder / CEO

Sendai Therapeutix

5月 2019 - 7月 2024

Senior Research Manager

Glycostem

5月 2018 - 4月 2019

学歴

Postdoc

UC San Diego

9月 2012 - 12月 2017

Postdoc

Salk Institute for Biological Studies

10月 2011 - 8月 2012

Ph.D. in Medical Sciences

Vrije Universiteit Brussel

10月 2004 - 12月 2010

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Tomas Bos, Ian J. Huggins, Olivia Gaylord, Christina Jessen, Brianna Lonquich, Angeline Puranen, Jenna Richter, Charlotte Rossdam, David Brafman, Terry Gaasterland, et al. (2017). The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells . Nature Communications.

Ranjan Batra, Thomas J Stark, Alex E. Clark, Jean-Philippe Belzile, Emily C Wheeler, Brian A Yee, Hui Huang, Chelsea Gelboin-Burkhart, Stephanie C Huelga, Stefan Aigner, et al. (2016). RNA-binding protein CPEB1 remodels host and viral RNA landscapes . Nature Structural & Molecular Biology.

Lode RY Goethals, Tomas J Bos, Luc Baeyens, Frank De Geeter, Nick Devoogdt, Tony Lahoutte (2014). Camelid reporter gene imaging: a generic method for in vivo cell tracking . EJNMMI Research.

Tomas Bos, Perpetua U. Emeagi, Sandra Van Lint, Cleo Goyvaerts, Sarah Maenhout, Anje Cauwels, Iain A. McNeish, Carlo Heirman, Kris Thielemans, Joeri L. Aerts, et al. (2012). Proinflammatory Characteristics of SMAC/DIABLO-Induced Cell Death in Antitumor Therapy . Cancer Research.

Marleen Keyaerts, Isabel Remory, Vicky Caveliers, Karine Breckpot, Tomas J. Bos, Jan Poelaert, Axel Bossuyt, Tony Lahoutte (2012). Inhibition of Firefly Luciferase by General Anesthetics: Effect on In Vitro and In Vivo Bioluminescence Imaging . PLoS ONE.

Petr Dmitriev, Andrei Petrov, Eugenie Ansseau, Luiza Stankevicins, Sébastien Charron, Elena Kim, Tomas Jan Bos, Thomas Robert, Ahmed Turki, Frédérique Coppée, et al. (2011). The Krüppel-like Factor 15 as a Molecular Link between Myogenic Factors and a Chromosome 4q Transcriptional Enhancer Implicated in Facioscapulohumeral Dystrophy . Journal of Biological Chemistry.

Tomas J. Bos, Elke De Bruyne, Sandra Van Lint, Carlo Heirman, Karin Vanderkerken (2010). Large double copy vectors are functional but show a size-dependent decline in transduction efficiency . Journal of Biotechnology.

Tomas J. Bos, Elke De Bruyne, Sandra Van Lint, Carlo Heirman, Karin Vanderkerken (2010). Large double copy vectors are functional but show a size-dependent decline in transduction efficiency . Journal of Biotechnology.

Elke De Bruyne, Tomas J. Bos, Frans Schuit, Els Van Valckenborgh, Eline Menu, Lieven Thorrez, Peter Atadja, Helena Jernberg-Wiklund, Karin Vanderkerken (2010). IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms . Blood.

J. Caers, D. Hose, I. Kuipers, T. J. Bos, E. Van Valckenborgh, E. Menu, E. De Bruyne, H. Goldschmidt, B. Van Camp, B. Klein, et al. (2010). Thymosin  4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma . Haematologica.

Tomas Bos, Elke De Bruyne, Carlo Heirman, Karin Vanderkerken (2009). In Search of the Most Suitable Lentiviral shRNA System . Current Gene Therapy.

Tomas Bos, Luc Baeyens, Stefan Bonné, Ilse Rooman, Cindy Peleman, Tony Lahoutte, Michael German, Harry Heimberg, Luc Bouwens (2009). Notch Signaling as Gatekeeper of Rat Acinar-to-β-Cell Conversion in Vitro . Gastroenterology.

Aude Bonehill, Sandra Tuyaerts, An MT Van Nuffel, Carlo Heirman, Tomas J Bos, Karel Fostier, Bart Neyns, Kris Thielemans (2008). Enhancing the T-cell Stimulatory Capacity of Human Dendritic Cells by Co-electroporation With CD40L, CD70 and Constitutively Active TLR4 Encoding mRNA . Molecular Therapy.

Elke De Bruyne, Tomas Jan Bos, Kewal Asosingh, Isabelle Vande Broek, Eline Menu, Els Van Valckenborgh, Peter Atadja, Valérie Coiteux, Xavier Leleu, Kris Thielemans, et al. (2008). Epigenetic Silencing of the Tetraspanin CD9 during Disease Progression in Multiple Myeloma Cells and Correlation with Survival . Clinical Cancer Research.

Marleen Keyaerts, Jacob Verschueren, Tomas J. Bos, Lea Olive Tchouate-Gainkam, Cindy Peleman, Karine Breckpot, Chris Vanhove, Vicky Caveliers, Axel Bossuyt, Tony Lahoutte (2008). Dynamic bioluminescence imaging for quantitative tumour burden assessment using IV or IP administration of d-luciferin: effect on intensity, time kinetics and repeatability of photon emission . European Journal of Nuclear Medicine and Molecular Imaging.

Tomas Bos, Elke De Bruyne, Sarah Deleu, Peter Atadja, Eline Menu, Els Van Valckenborgh, Ben Van Camp, Karin Vanderkerken (2007). Regulation of Bim Expression by IGF-1 in the 5T33MM Murine Model for Multiple Myeloma . Blood.

BOOK CHAPTER

Tomas J. Bos, Julia K. Nussbacher, Stefan Aigner, Gene W. Yeo (2016). Tethered Function Assays as Tools to Elucidate the Molecular Roles of RNA-Binding Proteins . Advances in Experimental Medicine and Biology.