プロフィール詳細

プロジェクトを作成

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Dr. Tyler G.に依頼

United States

Delivering the Impossible, Chemist, Formulations, Non-Viral Vectors, Gene Therapy Scientist and Engineer

プロフィール概要

PhD Scientist with expertise in the field of molecular pharmaceutics, pharmacoengineering, gene therapy, and medicinal/polymer/lipid chemistry committed to applying scientific knowledge and real world experiences to impact the clinical outcome of patients and improve agricultural practices.

専門分野

• ★ Medicinal Chemistry
• ★ Gene Therapy
• ★ Formulation

サービス

• Research
• Product Development

Research Fact Checking, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Product Development Formulation

職務経験

Scientist

Precision Biosciences

5月 2017 - 現在

学歴

University of North Carolina at Chapel Hill

- 現在

PhD, Molecular Pharmaceutics and Engineering

University of North Carolina Chapel Hill

8月 2013 - 5月 2017

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Das, M., Shen, L., Liu, Q., Goodwin, T.J., Huang, L.(2019). Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer . Molecular Therapy. 27. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 507-517.

Shen, L., Li, J., Liu, Q., Song, W., Zhang, X., Tiruthani, K., Hu, H., Das, M., Goodwin, T.J., Liu, R., et al.(2018). Local Blockade of Interleukin 10 and C-X-C Motif Chemokine Ligand 12 with Nano-Delivery Promotes Antitumor Response in Murine Cancers . ACS Nano.

Zhou, J., Liu, M., Sun, H., Feng, Y., Xu, L., Chan, A.W.H., Tong, J.H., Wong, J., Chong, C.C.N., Lai, P.B.S., et al.(2018). Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy . Gut. 67. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 931-944.

Song, W., Shen, L., Wang, Y., Liu, Q., Goodwin, T.J., Li, J., Dorosheva, O., Liu, T., Liu, R., Huang, L.(2018). Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap . Nature Communications. 9. (1).

Buchanan, M.K., Needham, C.N., Neill, N.E., White, M.C., Kelly, C.B., Mastro-Kishton, K., Chauvigne-Hines, L.M., Goodwin, T.J., McIver, A.L., Bartolotti, L.J., et al.(2017). Glycoconjugated site-selective DNA-methylating agent targeting glucose transporters on glioma cells . Biochemistry. 56. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 421-440.

Goodwin, T.J., Huang, L.(2017). Investigation of phosphorylated adjuvants co-encapsulated with a model cancer peptide antigen for the treatment of colorectal cancer and liver metastasis . Vaccine. 35. (19). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2550-2557.

Goodwin, T.J., Shen, L., Hu, M., Li, J., Feng, R., Dorosheva, O., Liu, R., Huang, L.(2017). Liver specific gene immunotherapies resolve immune suppressive ectopic lymphoid structures of liver metastases and prolong survival . Biomaterials. 141. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 260-271.

Hu, K., Miao, L., Goodwin, T.J., Li, J., Liu, Q., Huang, L.(2017). Quercetin Remodels the Tumor Microenvironment to Improve the Permeation, Retention, and Antitumor Effects of Nanoparticles . ACS Nano. 11. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4916-4925.

Miao, L., Li, J., Liu, Q., Feng, R., Das, M., Lin, C.M., Goodwin, T.J., Dorosheva, O., Liu, R., Huang, L.(2017). Transient and Local Expression of Chemokine and Immune Checkpoint Traps to Treat Pancreatic Cancer . ACS Nano. 11. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 8690-8706.

Luo, C., Sun, J., Sun, B., Liu, D., Miao, L., Goodwin, T.J., Huang, L., He, Z.(2016). Facile Fabrication of Tumor Redox-Sensitive Nanoassemblies of Small-Molecule Oleate Prodrug as Potent Chemotherapeutic Nanomedicine . Small. 12. (46). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6353-6362.

Goodwin, T.J., Zhou, Y., Musetti, S.N., Liu, R., Huang, L.(2016). Local and transient gene expression primes the liver to resist cancer metastasis . Science Translational Medicine. 8. (364).

Goodwin, T.J., Huang, L.(2016). On the article “Findings questioning the involvement of Sigma-1 receptor in the uptake of anisamide-decorated particles” [J. Control. Release 224 (2016) 229–238]: Letter to the Editor 1 (September 14, 2016) . Journal of Controlled Release. 243. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 382-385.

BOOK CHAPTER

Goodwin, T., Huang, L.(2014). Nonviral vectors. we have come a long way . Advances in Genetics. 88. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-12.