プロフィール詳細

プロジェクトを作成

★★★★★

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Dr. UDAY KUMAR K.に依頼

Czech Republic

"PhD Toxicologist Specializing in PDE Calculations & Omics Data Analysis Using R Studio"

プロフィール概要

I am a Ph.D. holder with specialized expertise in toxicology risk assessment for the pharmaceutical industry, focusing on permitted daily exposure (PDE) limits and occupational health-based exposure standards. Currently enhancing my knowledge through a Master's in Toxicology, I bring a rigorous scientific approach to safety evaluations and regulatory compliance. My core expertise includes: • Developing and validating PDE calculations for active pharmaceutical ingredients following ICH Q3C/Q3D guidelines • Conducting comprehensive toxicological risk assessments for pharmaceutical production facilities • Establishing science-based occupational exposure limits (OELs) for manufacturing environments • Interpreting complex toxicological data to support regulatory submissions I offer advanced data analysis capabilities through my proficiency with R Studio and Visual Studio Code, particularly for handling and interpreting complex omics datasets (genomics, proteomics, metabolomics). This computational expertise allows me to extract meaningful insights from large-scale toxicological data, providing clients with data-driven recommendations and visualizations. My interdisciplinary background combines toxicology principles with practical pharmaceutical applications, enabling me to bridge the gap between theoretical risk assessment and real-world implementation of safety standards. I have successfully helped pharmaceutical companies establish robust safety parameters that satisfy regulatory requirements while optimizing operational processes. I am available for consulting projects involving PDE calculations, toxicological risk assessments, omics data analysis, and regulatory documentation for pharmaceutical products and manufacturing processes.

専門分野

• ☆ Molecular Biology
• ☆ Omics
• ☆ Transcriptomics
• ☆ Comparative Genomics
• ☆ Proteomics
• ☆ Metabolomics
• ☆ Genomics
• ☆ Environmental Science
• ☆ Environmental Health
• ☆ Drug Development
• ☆ In vivo Preclinical Toxicology
• ☆ Pharmaceutical Regulatory Affairs
• ☆ Clinical Trials
• ☆ Medical Toxicology
• ☆ Health Risk Assessments
• ☆ Occupational Health & Safety
• ☆ Occupational Toxciology
• ☆ Workplace Safety Assessment
• ☆ Regulatory Affairs

サービス

• Writing

Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Copywriting

職務経験

Toxicologist

MoCare Technologies s.r.o

1月 2021 - 現在

Lecturer (External)

University of South Bohemia in České Budějovice

2月 2019 - 現在

Research Associate

Biology Centre

10月 2017 - 12月 2021

学歴

Master Program in Toxicology (Toxicology)

University of Eastern Finland

9月 2022 - 6月 2025

Ph.D. (Department of Biochemistry)

Charles University

10月 2010 - 9月 2015

Masters in Pharmaceutical Sciences

University of Gothenburg

1月 2008 - 8月 2010

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Uday Kumar Killi, Matěj Malík, Zdeňka Navrátilová, Radoslav Patočka, Patrik Olekšák, Sireesha Uday Killi, Kamil Kuca, Pavel Tlustoš, Jiří Patočka (2024). Exploring the biomedical applications of Campsis radicans (woody vine): integrating traditional wisdom and contemporary insights . Phytochemistry Reviews.

Dr. Uday Kumar Killi, Matěj Malík, Zdeňka Navrátilová, Radoslav Patočka, Patrik Olekšák, Sireesha Uday Killi, Kamil Kuca, Pavel Tlustos, Jiri Patocka (2024). Exploring the biomedical applications of Campsis radicans (woody vine): integrating traditional wisdom and contemporary insights . Phytochemistry Reviews.

Matěj Malík, Lucie Malá, Uday Kumar Killi, Bohumír Plucar, Otakar Jiří Mika, Zdeňka Navrátilová, Patrik Olekšák, Jiří Patočka (2024). AGARITINE: A NATURAL TOXIC AMINO ACID OF CULTIVATED MUSHROOM AGARICUS SPP. AND ITS POTENTIAL HEALTH RISK . Military Medical Science Letters.

Matěj Malík, Lucie Malá, Dr. Uday Kumar Killi, Bohumír Plucar, Otakar Jiří MIKA, Zdeňka Navrátilová, Patrik Olekšák, Jiri Patocka (2024). AGARITINE: A NATURAL TOXIC AMINO ACID OF CULTIVATED MUSHROOM AGARICUS SPP. AND ITS POTENTIAL HEALTH RISK . Military Medical Science Letters.

Malik, Matej, Mika, Otakar Jiri, Navratilova, Zdenka, Killi, Uday Kumar, Tlustos, Pavel, Patocka, Jiri (2024). Health and Environmental Hazards of the Toxic <i>Pteridium aquilinum</i> (L.) Kuhn (Bracken Fern) . Plants.

Matěj Mal&#237;k, Otakar Jiř&#237; Mika, Zdeňka Navr&#225;tilov&#225;, Uday Kumar Killi, Pavel Tlustoš, Jiř&#237; Patočka (2023). Health and Environmental Hazards of the Toxic Pteridium aquilinum (L.) Kuhn (Bracken Fern) . Plants.

Matěj Mal&#237;k, Otakar Jiř&#237; MIKA, Zdeňka Navr&#225;tilov&#225;, Dr. Uday Kumar Killi, Pavel Tlustos, Jiri Patocka (2023). Health and Environmental Hazards of the Toxic <i>Pteridium aquilinum</i> (L.) Kuhn (Bracken Fern) . Plants.

Dr. Uday Kumar Killi(2022). Molecular modelling on multiepitope-based vaccine against SARS-CoV-2 using immunoinformatics, molecular docking, and molecular dynamics simulation . SAR and QSAR in Environmental Research. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--27. Informa {UK} Limited

Jiř&#237; Patočka, Zdeňka Navr&#225;tilov&#225;, Kamil Kuča, Patrik Olekš&#225;k, Uday Kumar Killi (2021). CAN BAICALEIN BECOME A NEW DRUG FOR COVID-19? . Military Medical Science Letters.

Ji{\v{r}}{\'{\i}} Pato{\v{c}}ka and Zde{\v{n}}ka Navr{\'{a}}tilov{\'{a}} and Kamil Ku{\v{c}}a and Patrik Olek{\v{s}}{\'{a}}k and Uday Kumar Killi(2021). CAN BAICALEIN BECOME A NEW DRUG FOR COVID-19? . Military Medical Science Letters. Faculty of Military Health Sciences, University of Defence

Mishra, Ajay Kumar, Kocabek, Tomas, Sukumari Nath, Vishnu, Awasthi, Praveen, Shrestha, Ankita, Kumar Killi, Uday, Jakse, Jernej, Patzak, Josef, Krofta, Karel, Matousek, Jaroslav (2020). Dissection of Dynamic Transcriptome Landscape of Leaf, Bract, and Lupulin Gland in Hop (Humulus lupulus L.) . International Journal of Molecular Sciences.

Ajay Kumar Mishra, Tom&#225;š Koc&#225;bek, Vishnu Sukumari Nath, Praveen Awasthi, Ankita Shrestha, Uday Kumar Killi, Jernej Jakse, Josef Patzak, Karel Krofta, Jaroslav Matoušek (2019). Dissection of Dynamic Transcriptome Landscape of Leaf, Bract, and Lupulin Gland in Hop (Humulus lupulus L.) . International Journal of Molecular Sciences.

Ajay Kumar Mishra, Tomas Kocabek, Vishnu Sukumari Nath, Praveen Awasthi, Ankita Shrestha, Dr. Uday Kumar Killi, Jernej Jakse, Josef Patzak, Karel Krofta, Jaroslav Matousek (2019). Dissection of Dynamic Transcriptome Landscape of Leaf, Bract, and Lupulin Gland in Hop (<i>Humulus lupulus</i> L.) . International Journal of Molecular Sciences.

Mishra, Ajay Kumar, Kumar, Atul, Mishra, Deepti, Nath, Vishnu Sukumari, Jakse, Jernej, Kocabek, Tomas, Killi, Uday Kumar, Morina, Filis, Matousek, Jaroslav (2018). Genome-Wide Transcriptomic Analysis Reveals Insights into the Response to <i>Citrus bark cracking viroid</i> (CBCVd) in Hop (<i>Humulus lupulus</i> L.) . Viruses.

Mishra, Ajay, Kumar, Atul, Mishra, Deepti, Nath, Vishnu, Jakše, Jernej, Koc&#225;bek, Tom&#225;š, Killi, Uday, Morina, Filis, Matoušek, Jaroslav(2018). Genome-Wide Transcriptomic Analysis Reveals Insights into the Response to Citrus bark cracking viroid (CBCVd) in Hop (Humulus lupulus L.) . Viruses. 10. (10).

Soukup, Ondrej, Winder, Michael, Killi, Uday Kumar, Wsol, Vladimir, Jun, Daniel, Kuca, Kamil, Tobin, Gunnar (2017). Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors-Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment . Current Neuropharmacology.

Soukup, Ondrej, Winder, Michael, Killi, Uday Kumar, Wsol, Vladimir, Jun, Daniel, Kuca, Kamil, Tobin, Gunnar(2017). Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors-Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment . Current Neuropharmacology. 15. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 637-653.

Killi, Uday K., Wsol, Vladimir, Soukup, Ondrej, Kuca, Kamil, Winder, Michael, Tobin, Gunnar (2014). In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat . Clinical and Experimental Pharmacology and Physiology.

Killi, Uday K., Wsol, Vladimir, Soukup, Ondrej, Kuca, Kamil, Winder, Michael, Tobin, Gunnar(2014). In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat . Clinical and Experimental Pharmacology and Physiology. 41. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 139-146.

Soukup, O., Krusek, J., Kaniakova, M., Kumar, U. K., Oz, M., Jun, D., Fusek, J., Kuca, K., Tobin, G. (2011). Oxime Reactivators and Their in Vivo and in Vitro Effects on Nicotinic Receptors . Physiological Research.

Soukup, O., Krusek, J., Kaniakova, M., Kumar, U. K., Oz, M., Jun, D., Fusek, J., Kuca, K., Tobin, G.(2011). Oxime Reactivators and Their in Vivo and in Vitro Effects on Nicotinic Receptors . Physiological Research. 60. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 679-686.

Soukup, O., Kumar, U. K., Proska, J., Bratova, L., Adem, A., Jun, D., Fusek, J., Kuca, K., Tobin, G. (2011). The effect of oxime reactivators on muscarinic receptors: Functional and binding examinations . Environmental Toxicology and Pharmacology.

Soukup, O., Kumar, U. K., Proska, J., Bratova, L., Adem, A., Jun, D., Fusek, J., Kuca, K., Tobin, G.(2011). The effect of oxime reactivators on muscarinic receptors: Functional and binding examinations . Environmental Toxicology and Pharmacology. 31. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 364-370.

Soukup, Ondrej, Tobin, Gunnar, Kumar, Uday Killi, Jun, Daniel, Fusek, Josef, Kuca, Kamil (2010). Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder . Toxicology Mechanisms and Methods.

Soukup, Ondrej, Tobin, Gunnar, Kumar, Uday Killi, Jun, Daniel, Fusek, Josef, Kuca, Kamil(2010). Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder . Toxicology Mechanisms and Methods. 20. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 428-433.

Soukup, O., Tobin, G., Kumar, U. K., Binder, J., Proska, J., Jun, D., Fusek, J., Kuca, K. (2010). Interaction of Nerve Agent Antidotes with Cholinergic Systems . Current Medicinal Chemistry.

Soukup, Ondrej, Holas, Ondrej, Binder, Jiri, Killy, Kumar, Tobin, Gunnar, Jun, Daniel, Fusek, Josef, Kuca, Kamil (2010). The effect of trimedoxime on acetylcholinesterase and on the cholinergic system of the rat bladder . Journal of Applied Biomedicine.

Soukup, O., Tobin, G., Kumar, U. K., Binder, J., Proska, J., Jun, D., Fusek, J., Kuca, K.(2010). Interaction of Nerve Agent Antidotes with Cholinergic Systems . Current Medicinal Chemistry. 17. (16). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1708-1718.

Soukup, Ondřej, Holas, Ondřej, Binder, Jiř&#237;, Killy, Kumar, Tobin, Gunnar, Jun, Daniel, Fusek, Josef, Kuča, Kamil(2010). The effect of trimedoxime on acetylcholinesterase and on the cholinergic system of the rat bladder . Journal of Applied Biomedicine. 8. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 87-92.

BOOK

(2016). Interactions of muscarinic receptors and cholineesterases. LAP LAMBERT Academic Publishing (May 31, 2016).