プロフィール詳細

プロジェクトを作成

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Dr. Vinit S.に依頼

India

Young Scientist_Cancer & Inflammation Expert_PhD in Biomedical Science_Experianced Researcher

プロフィール概要

I am a biomedical scientist with over 8 years of research experience in cancer biology, chronic inflammation, and translational medicine, currently completing an independent Young Scientist Fellowship funded by ICMR-DHR, Government of India. I hold a Ph.D. in Biomedical Science from PGIMER, Chandigarh, where my research focused on the role of Myeloid-Derived Suppressor Cells (MDSCs) in tumor progression and immune modulation in pancreatic cancer. I’ve worked extensively on clinical samples (tissue, blood, urine, and saliva), as well as cancer cell lines (e.g., PANC-1). I have hands-on experience in mitophagy, apoptosis, EMT, and stemness-related pathways, particularly those involving mitochondrial dysfunction and the PINK1/Parkin axis. As part of my ongoing fellowship, I am investigating the anti-tumor potential of natural flavonoids (Morin, Fisetin), in combination with gemcitabine, using molecular, cellular, and in silico approaches. I have authored several publications, presented at national and international forums, and reviewed research articles for reputed journals. Core Skills & Expertise: i. Gene expression analysis (qPCR, PCR arrays) ii. Protein analysis (Western blot, ELISA) iii. Cell viability, migration, invasion, and spheroid assays iv. ROS, mitochondrial membrane potential, ALDH activity assays v. Scientific writing & editing (manuscripts, abstracts, grants) vi. Immunofluorescence & confocal microscopy vii. In silico molecular docking & toxicity prediction Freelance Services Offered: i. Thesis, Research, and Review Paper Writing Support ii. Manuscript editing and scientific proofreading iii. Data interpretation & literature review iv. Statistical Analysis v. Grant proposal and abstract writing vi. Experimental design consultation vii. Translational science consulting (cancer/inflammation focus) viii. Data analysis support for molecular biology and in vitro experiments ix. Flowcytometry data analysis and panel support x. College and University project support I bring to the table a deep understanding of disease mechanisms, experience working with clinicians, and a strong commitment to high-quality, impactful science. I look forward to collaborating on scientific and medical writing, consulting, and research support projects.

専門分野

• ☆ Computational Biology
• ☆ Microbiology
• ☆ Biostatistics
• ☆ Zoology
• ☆ Mammalian Biology
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Structural Biology
• ☆ Apoptosis
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Antioxidants
• ☆ Enzyme Activity Assays
• ☆ Binding Assays
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Microarrays
• ☆ Omics
• ☆ Transcriptomics
• ☆ Comparative Genomics
• ☆ Proteomics
• ☆ Metabolomics
• ☆ PCR
• ☆ Next Generation Sequencing (NGS)
• ☆ DNA Sequencing
• ☆ Gene Expression Analysis
• ☆ Exome Sequencing
• ☆ RNA Synthesis
• ☆ RNA Sequencing
• ☆ Histology
• ☆ Biotechnology & Bioengineering
• ☆ Microscopy
• ☆ Cryosectioning
• ☆ Light Microscopy
• ☆ Electron Microscopy
• ☆ Fluorescence Microscopy
• ☆ Environmental Science
• ☆ Environmental Biotechnology
• ☆ Environmental Health
• ☆ Food Microbiology
• ☆ Clinical Microbiology
• ☆ Biomarker Discovery
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Forensic Genetics
• ☆ Tissue Engineering
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ In vitro Diagnostics
• ☆ In vitro Diagnostic Validation
• ☆ In vitro Diagnostic Design
• ☆ Biomarker Analysis
• ☆ Clinical Trials
• ☆ Patient Recruitment
• ☆ Medical Genetics
• ☆ Immunogenetics
• ☆ Human Biology
• ☆ Hematology
• ☆ Hematology-Oncology
• ☆ Health Technology Assessment
• ☆ Hemophilia
• ☆ Inflammation

サービス

• Writing

Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Copywriting, Creative Writing, Newswriting, General Proofreading & Editing, Translation

職務経験

Young Scientist

PGIMER

- 現在

Young Scientist, Principal Investigator

Post graduate institute of medical education and research Chandigarh

12月 2021 - 7月 2025

学歴

PhD

Post graduate institute of medical education and research Chandigarh

11月 2016 - 11月 2021

PhD (Anatomy and cell molecular biology)

Post Graduate Institute of Medical Education and Research

11月 2016 - 11月 2021

MSc

Himachal Pradesh University Shimla

7月 2014 - 6月 2016

認定資格

• Intellectual Property Rights and Patents

  Panjab University Chandigarh

  1月 2025 - 現在

• Multi Omics Data Analysis

  ICMR and Next Gen Helper

  6月 2024 - 現在

• Advance Flowcytometry Certificate Course

  BD Biosciences

  9月 2017 - 現在

• Qualification in Immunohistochemistry

  Post graduate institute of medical education and research Chandigarh

  1月 2017 - 現在

• Research Methodology and Biostatistics

  Post graduate institute of medical education and research Chandigarh

  1月 2016 - 現在

出版物

JOURNAL ARTICLE

Vinit Sharma, Justin Jacob, Aditya Aggarwal, Shalmoli Bhattacharyya, Daisy Sahni, Anjali Aggarwal (2025). Fisetin and resveratrol exhibit senotherapeutic effects and suppress cellular senescence in osteoarthritic cartilage-derived chondrogenic progenitor cells . European Journal of Pharmacology.

Vinit Sharma, Ankita Arora, Sakshi Bansal, Ankita Semwal, Mayank Sharma, Anjali Aggarwal (2024). Role of bio‐flavonols and their derivatives in improving mitochondrial dysfunctions associated with pancreatic tumorigenesis . Cell Biochemistry and Function.

Vinit Sharma, Sakshi Bansal, Rajesh Gupta, Harjeet Singh, Anjali Aggarwal(2024). A New Approach for Assessment of Neutrophil Extracellular Traps Through Immunofluorescence Staining in Whole Blood Smears . BIO-PROTOCOL. 14. (1346). Bio-Protocol, LLC

Vinit Sharma, ANKITA Arora, Rajesh Gupta, Anjali Aggarwal(2024). Isolation and Characterization of Extracellular Vesicles Derived from Ex Vivo Culture of Visceral Adipose Tissue . BIO-PROTOCOL. 14. (1346). Bio-Protocol, LLC

CCR4+ monocytic myeloid-derived suppressor cells are associated with the increased epithelial-mesenchymal transition in pancreatic adenocarcinoma patients @article{Sharma_2022, title={CCR4+ monocytic myeloid-derived suppressor cells are associated with the increased epithelial-mesenchymal transition in pancreatic adenocarcinoma patients}, volume={227}, ISSN={0171-2985}, url={http://dx.doi.org/10.1016/j.imbio.2022.152210}, DOI={10.1016/j.imbio.2022.152210}, number={3}, journal={Immunobiology}, publisher={Elsevier BV}, author={Sharma, Vinit and Sachdeva, Naresh and Gupta, Vikas and Nada, Ritambhra and Jacob, Justin and Sahni, Daisy and Aggarwal, Anjali}, year={2022}, month=may, pages={152210} } . Immunobiology.

Senescent chondrogenic progenitor cells derived from articular cartilage of knee osteoarthritis patients contributes to senescence-associated secretory phenotype via release of IL-6 and IL-8 @article{Jacob_2022, title={Senescent chondrogenic progenitor cells derived from articular cartilage of knee osteoarthritis patients contributes to senescence-associated secretory phenotype via release of IL-6 and IL-8}, volume={124}, ISSN={0065-1281}, url={http://dx.doi.org/10.1016/j.acthis.2022.151867}, DOI={10.1016/j.acthis.2022.151867}, number={3}, journal={Acta Histochemica}, publisher={Elsevier BV}, author={Jacob, Justin and Aggarwal, Anjali and Aggarwal, Aditya and Bhattacharyya, Shalmoli and Kumar, Vishal and Sharma, Vinit and Sahni, Daisy}, year={2022}, month=apr, pages={151867} } . Acta Histochemica.

Vinit Sharma, Naresh Sachdeva, Vikas Gupta, Ritambhra Nada, Justin Jacob, Daisy Sahni, Anjali Aggarwal(2021). IL‐6 is associated with expansion of myeloid‐derived suppressor cells and enhanced immunosuppression in pancreatic adenocarcinoma patients . Scandinavian Journal of Immunology. Wiley

Vinit Sharma, Saurabh Kumar, Subhabrata Sarkar, Abhilash Ludhiadch(2021). Battle against the pandemic: Emergence of SARS-CoV2 variants and global challenge . Travel Medicine and Infectious Disease. 44. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 102173. Elsevier {BV}

Vinit Sharma, Anjali Aggarwal, Justin Jacob, Daisy Sahni (2021). Myeloid‐derived suppressor cells: Bridging the gap between inflammation and pancreatic adenocarcinoma . Scandinavian Journal of Immunology.

e12770. Sachdeva M, Aggarwal A, Sharma R, Randhawa A, Sahni D, Jacob J, Sharma V, Aggarwal A. Chronic inflammation during osteoarthritis is associated with an increased expression of CD161 during advanced stage. Scandinavian journal of immunology. 2019 Jul;90(1):e12770.

BOOK CHAPTER

Vinit Sharma, Anjali Aggarwal, Justin Jacob, Ankita Semwal, Daisy Sahni(2024). Metabolite-Based Biosignature of Pancreatic Cancer . Molecular Biomarkers for Cancer Diagnosis and Therapy. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 319–345. Springer Nature Singapore

CONFERENCE POSTER

(2019). Increased level of Myeloid Derived Suppressor Cells is associated with Enhanced Immunosuppressive and inflammatory potential in Pancreatic Ductal Adenocarcinoma Patients. XLIII ALL INDIA CELL BIO CONFERENCE IISER MOHALI.