プロフィール詳細

プロジェクトを作成

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Vladimir F.に依頼

Czech Republic

Drug discovery chemist skilled in SAR analysis, metabolic optimization, and molecular design

プロフィール概要

I am a medicinal chemist with a passion for translating chemical ideas into real therapeutic opportunities. My background combines synthetic organic chemistry, drug design, and biological insight, enabling me to approach problems holistically—from concept to synthesis and functional validation. I focus on the discovery and optimization of antimicrobial agents, with a strong emphasis on structure–activity relationship (SAR) expansion, metabolic stability improvement, and the design of synthetically feasible small molecules. Over the past years, I have contributed to multiple preclinical discovery projects targeting key mycobacterial transporters such as MmpL3 and DprE1, where I applied integrated medicinal chemistry and in silico modeling to design and refine novel scaffolds with enhanced potency and drug-like properties. My experience also includes developing derivatization methods for the detection of chemical warfare agent degradation products and designing fluorophores for advanced material applications. I bring a practical mindset to molecular design — always considering synthetic accessibility, precursor availability, and downstream scalability. Beyond laboratory work, I have strong experience in early-stage research ideation, proposal writing, and project management, with a track record of successfully initiating and leading grant-funded studies. I am skilled in advanced scientific visualization using ChemDraw and BioRender, which I use to communicate complex ideas effectively and align interdisciplinary teams around shared project goals. My approach combines creativity, analytical precision, and strategic thinking, aimed at transforming promising molecular concepts into viable, high-value assets for research and development.

専門分野

• ☆ Organic Chemistry
• ☆ Retrosynthesis
• ☆ Drug Discovery
• ☆ Medicinal Chemistry
• ☆ Pulmonology/Respiratory Disease
• ☆ Tuberculosis

サービス

• Writing
• Research
• Consulting

Writing General Proofreading & Editing

Research Feasibility Study, Technology Scouting, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

職務経験

Research Scientist

Charles University in Prague

1月 2024 - 現在

Research Scientist

University Hospital Hradec Králové

1月 2020 - 現在

Postdoc (visiting)

University of Ljubljana

9月 2025 - 12月 2025

PhD visiting student

Kings College London

3月 2021 - 9月 2021

学歴

Ph.D., Chemistry

Charles University Prague - Czech Republic

1月 2025 - 1月 2025

M.Sc (Master of Science)

University of Pardubice - Czech Republic

9月 2017 - 6月 2019

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Vladimir Finger, Ondrej Kovar, Martin Kufa, Ondrej Soukup, Martin Kratky, Carilyn Torruellas, Jaroslav Roh, Jan Korabecny (2025). Scaffold Hopping in Tuberculosis Drug Discovery: Principles, Applications, and Case Studies . Journal of Medicinal Chemistry.

Vladimir Finger, Martin Vrbicky, Lubica Muckova, Lukas Prchal, Martin Novak, Jan Marek, Ondrej Soukup, Michaela Hympanova, Ales Sorf, Marketa Benkova, et al. (2025). Novel antitubercular agents based on 2,4-disubstituted 5-(aryl-2-ylmethyl)-5H-pyrrolo[3,2-d]pyrimidines . Biomedicine & Pharmacotherapy.

Vladimir Finger, Jakub Opravil, Jaroslav Pejchal, Jan Korabecny, Tomas Rozsypal, Martina Hrabinova, Lubica Muckova, Vendula Hepnarova, Jan Konecny, Ondrej Soukup, et al. (2023). A-agents, misleadingly known as “Novichoks”: a narrative review . Archives of Toxicology.

Vladimir Finger, Barbora Svobodova, Lenka Pulkrabkova, Dawid Panek, Anna Misiachna, Marharyta Kolcheva, Rudolf Andrys, Jiri Handl, Jan Capek, Pavlina Nyvltova, et al. (2023). Structure-Guided Design of <i>N</i>-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer’s Disease . International Journal of Molecular Sciences.

PREPRINT

Vladimir Finger, Barbora Svobodova, Zuzana Moravcova, Anna Misiachna, Gabriela Novakova, Ales Marek, Jitka Odvarkova, Jaroslav Pejchal, Jana Karasova Zdarova, Jakub Netolicky, et al. (2025). Novel Tacrine-Based Compounds: Bridging Cholinesterase Inhibition and NMDAR Antagonism .