プロフィール詳細

プロジェクトを作成

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Dr. Wei-Hua C.に依頼

United States

Neurobiologist with 10+ years' experience of aniaml models of Parkinson's disease| Translational Research Advisor

プロフィール概要

I am professional and efficient neurobiologist with 10+ years’ experience and knowledge of state-of-art translational research, focusing on biology, physiology, behavior, and histopathogy in clinical-relevant phenotype in small animal models of neurodegenerative diseases. My expertise is to choose and generate animal models to: 1. test compound and drugs efficacy and develop functional assay to evaluate the therapeutic effects; 2. investigate the symptom-relevant biological mechanisms for potential biomarkers and drug discovery.

専門分野

• ☆ Neuroscience
• ☆ Neurophysiology
• ☆ Behavioral Neuroscience
• ☆ Neuroanatomy
• ☆ Neuropharmacology
• ☆ Neurobiology
• ☆ Systems Neuroscience
• ☆ Biophysics
• ☆ Histology

サービス

• Writing
• Research
• Consulting

Writing Technical Writing, General Proofreading & Editing, Translation

Research Feasibility Study, Scientific and Technical Research, Systematic Literature Review

Consulting Healthcare Consulting, Scientific and Technical Consulting

職務経験

Research Scientist

NYU Langone Health

4月 2020 - 現在

Postdoctoral Researcher

Hebrew University Hadassah Medical School

2月 2016 - 2月 2020

学歴

Ph.D (Neurology)

Philipps University of Marburg

7月 2008 - 12月 2013

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Katrin Sakreida, Wei-Hua Chiu, Juergen Dukart, Simon B. Eickhoff, Thomas Frodl, Christian Gaser, Michael Landgrebe, Berthold Langguth, Daniela Mirlach, I Sabina Rautu, et al.(2022). Disentangling dyskinesia from parkinsonism in motor structures of patients with schizophrenia . Brain Communications. 4. (4). Oxford University Press ({OUP})

Matschke, L.A., Komadowski, M.A., Stöhr, A., Lee, B., Henrich, M.T., Griesbach, M., Rinné, S., Geibl, F.F., Chiu, W.-H., Koprich, J.B., et al.(2022). Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease . Scientific Reports. 12. (1).

Wei-Hua Chiu, Lora Kovacheva, Ruth E. Musgrove, Hadar Arien-Zakay, James B. Koprich, Jonathan M. Brotchie, Rami Yaka, Danny Ben-Zvi, Menachem Hanani, Jochen Roeper, et al. (2021). α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms . Science Advances.

Chiu, W.-H., Kovacheva, L., Musgrove, R.E., Arien-Zakay, H., Koprich, J.B., Brotchie, J.M., Yaka, R., Ben-Zvi, D., Hanani, M., Roeper, J., et al.(2021). α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms . Science Advances. 7. (11).

Rotem Rehani, Yara Atamna, Lior Tiroshi, Wei-Hua Chiu, José de Jesús Aceves Buendía, Gabriela J. Martins, Gilad A. Jacobson, Joshua A. Goldberg (2019). Activity Patterns in the Neuropil of Striatal Cholinergic Interneurons in Freely Moving Mice Represent Their Collective Spiking Dynamics . eneuro.

Aceves Buendia, J.J., Tiroshi, L., Chiu, W.-H., Goldberg, J.A.(2019). Selective remodeling of glutamatergic transmission to striatal cholinergic interneurons after dopamine depletion . European Journal of Neuroscience. 49. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 824-833.

Thakur, P., Chiu, W.H., Roeper, J., Goldberg, J.A.(2019). α-Synuclein 2.0 — Moving towards Cell Type Specific Pathophysiology . Neuroscience. 412. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 248-256.

Rehani, R., Atamna, Y., Tiroshi, L., Chiu, W.-H., Aceves Buendía, J.J., Martins, G.J., Jacobson, G.A., Goldberg, J.A.(2019). Activity patterns in the neuropil of striatal cholinergic interneurons in freely moving mice represent their collective spiking dynamics . eNeuro. 6. (1).

Henrich, M.T., Geibl, F.F., Lee, B., Chiu, W.-H., Koprich, J.B., Brotchie, J.M., Timmermann, L., Decher, N., Matschke, L.A., Oertel, W.H.(2018). A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia . Acta neuropathologica communications. 6. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 39.

Efrat Lasser-Katz, Alon Simchovitz, Wei-Hua Chiu, Wolfgang H. Oertel, Ronit Sharon, Hermona Soreq, Jochen Roeper, Joshua A. Goldberg (2017). Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease . The Journal of Neuroscience.

Efrat Lasser-Katz, Alon Simchovitz, Wei-Hua Chiu, Wolfgang H. Oertel, Ronit Sharon, Hermona Soreq, Jochen Roeper, Joshua A. Goldberg (2017). Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease . The Journal of Neuroscience.

Höllerhage, M., Moebius, C., Melms, J., Chiu, W.-H., Goebel, J.N., Chakroun, T., Koeglsperger, T., Oertel, W.H., Rösler, T.W., Bickle, M., et al.(2017). Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells . Scientific Reports. 7. (1).

Lasser-Katz, E., Simchovitz, A., Chiu, W.-H., Oertel, W.H., Sharon, R., Soreq, H., Roeper, J., Goldberg, J.A.(2017). Mutant α -synuclein overexpression induces stressless pacemaking in vagal motoneurons at risk in parkinson’s disease . Journal of Neuroscience. 37. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 47-57.

Klietz, M., Keber, U., Carlsson, T., Chiu, W.-H., Höglinger, G.U., Weihe, E., Schäfer, M.K.-H., Depboylu, C.(2016). L-DOPA-induced dyskinesia is associated with a deficient numerical downregulation of striatal tyrosine hydroxylase mRNA-expressing neurons . Neuroscience. 331. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 120-133.

Chiu, W.-H., Depboylu, C., Hermanns, G., Maurer, L., Windolph, A., Oertel, W.H., Ries, V., Höglinger, G.U.(2015). Long-term treatment with l-DOPA or pramipexole affects adult neurogenesis and corresponding non-motor behavior in a mouse model of Parkinson's disease . Neuropharmacology. 95. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 367-376.

Chiu, W.-H., Carlsson, T., Depboylu, C., Höglinger, G.U., Oertel, W.H., Ries, V.(2014). Selegiline normalizes, while l-DOPA sustains the increased number of dopamine neurons in the olfactory bulb in a 6-OHDA mouse model of Parkinson's disease . Neuropharmacology. 79. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 212-221.

PREPRINT

Wei-Hua Chiu, Lora Kovacheva, Ruth E. Musgrove, Hadar Arien-Zakay, James B. Koprich, Jonathan M. Brotchie, Rami Yaka, Danny Ben-Zvi, Menachem Hanani, Jochen Roeper, et al. (2019). α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons causes non-motor parkinsonian symptoms .

OTHER

Rehani, R., Atamna, Y., Tiroshi, L., Chiu, W.-H., Aceves Buendía, J.D.J., Martins, G.J., Jacobson, G.A., Goldberg, J.A.(2018). Wave-like activity patterns in the neuropil of striatal cholinergic interneurons in freely moving mice represent their collective spiking dynamics . bioRxiv.

BOOK

Arias-Carrión, O., Yamada, E., Freundlieb, N., Djufri, M., Maurer, L., Hermanns, G., Ipach, B., Chiu, W.-H., Steiner, C., Oertel, W.H., et al.(2009). Neurogenesis in substantia nigra of Parkinsonian brains? . Journal of Neural Transmission, Supplementa. (73). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 279-285.