プロフィール詳細

プロジェクトを作成

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Dr. William D.に依頼

United States

Scientific Consultant | Immunology, Microbiome, Clinical Trials, & Medical Writing

プロフィール概要

PhD-trained scientist and executive-level consultant with 20+ years of experience spanning academia, biotech, and translational medicine. I specialize in immunology, microbiome research, inflammation, infectious diseases, and clinical trial design. I’ve directed multi-million dollar research programs, built and led cross-functional teams, and served as a strategic advisor to startups and global organizations alike. My expertise includes scientific writing, grant development, protocol design, and high-impact content creation for technical and non-technical audiences. I’ve contributed to peer-reviewed publications in Nature, Science, and Cell Host & Microbe, and have extensive experience translating complex data into actionable insights for clinicians, investors, and R&D teams. As a consultant, I bring precision, creativity, and scientific rigor to every project—whether it’s developing CME-accredited materials, crafting investor-ready pitch decks, or reviewing clinical protocols. I’ve worked with CROs, VC-backed biotech companies, and media outlets like BuzzFeed and Oprah Magazine to ensure scientific credibility and clarity. If you’re seeking a thought partner who can navigate the intersection of science, strategy, and communication, I bring both deep technical knowledge and an ability to connect the dots between data, people, and impact. Areas of expertise: human microbiome, infectious and inflammatory diseases, nutrition and mucosal immunology 20 years of continuous NIH funding, and several high profile publications and discoveries Please check out my LinkedIn profile for further details: http://www.linkedin.com/in/williamdepaolo/

専門分野

• ★ Microbiome Research
• ★ Basic Immunology
• ★ Infectious Disease
• ☆ Microbiology
• ☆ Microbiological Assays
• ☆ Bacteriology
• ☆ Gram-Negative Bacteria
• ☆ Gram-Positive Bacteria
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ PCR
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Stem Cell Research
• ☆ Adjuvant & Antigen Research
• ☆ Bioinformatics
• ☆ Food Science
• ☆ Nutrition Science
• ☆ Pathogenesis
• ☆ Primary Cells
• ☆ 3D Cell Culture
• ☆ Allergy & Clinical Immunology
• ☆ Clinical Immunology
• ☆ Gastroenterology & Hepatology
• ☆ Colorectal Cancer
• ☆ Inflammation
• ☆ Cancer Research
• ☆ Metabolism & Metabolic Disease

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Creative Writing, General Proofreading & Editing

Research Fact Checking, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Business Strategy Consulting, Healthcare Consulting, Scientific and Technical Consulting

Data & AI Data Visualization, Data Insights

Product Development Concept Development

職務経験

Associate Professor of Medicine and Endowed Chair in Gastroenterology

University of Washington

10月 2016 - 現在

Assistant Professor

Keck Hospital of USC

4月 2011 - 10月 2016

Research Assistant Professor

University of Chicago

6月 2007 - 3月 2011

Postdoctoral Fellow

University of Chicago

6月 2004 - 5月 2007

学歴

PhD (Immunology & Microbial Pathogenesis)

Northwestern University Feinberg School of Medicine

8月 1999 - 4月 2004

Bachelor Science (Neuroscience)

Bates College

8月 1995 - 5月 1999

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Okazaki S, Loupakis F, Stintzing S, Cao S, Zhang W, Yang D, Ning Y, Sunakawa Y, Stremitzer S, Matsusaka S, Berger MD. Clinical significance of TLR1 I602S polymorphism for patients with metastatic colorectal cancer treated with FOLFIRI plus bevacizumab. Molecular cancer therapeutics. 2016 Jul 1;15(7):1740-5.

Kamdar, K., Khakpour, S., Chen, J., Leone, V., Brulc, J., Mangatu, T., Antonopoulos, D.A., Chang, E.B., Kahn, S.A., Kirschner, B.S., et al.(2016). Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease . Cell Host and Microbe. 19. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 21-31.

Nguyen, V., Pearson, K., Kim, J.-H., Kamdar, K., DePaolo, R.W.(2015). Retinoic acid can exacerbate T cell intrinsic TLR2 activation to promote tolerance . PLoS ONE. 10. (3).

Michail, S., Bultron, G., Depaolo, R.W.(2013). Genetic variants associated with Crohn's disease . Application of Clinical Genetics. 6. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 25-32.

Kamdar, K., Nguyen, V., DePaolo, R.W.(2013). Toll-like receptor signaling and regulation of intestinal immunity . Virulence. 4. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 207-212.

Sugiura, Y., Kamdar, K., Khakpour, S., Young, G., Karpus, W.J., DePaolo, R.W.(2013). TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica . Mucosal Immunology. 6. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1101-1109.

Depaolo, R.W., Abadie, V., Tang, F., Fehlner-Peach, H., Hall, J.A., Wang, W., Marietta, E.V., Kasarda, D.D., Waldmann, T.A., Murray, J.A., et al.(2011). Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens . Nature. 471. (7337). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 220-225.

Elhofy, A., DePaolo, R.W., Lira, S.A., Lukacs, N.W., Karpus, W.J.(2009). Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis . Journal of Neuroimmunology. 213. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 91-99.

DePaolo, R.W., Tang, F., Kim, I., Han, M., Levin, N., Ciletti, N., Lin, A., Anderson, D., Schneewind, O., Jabri, B.(2008). Toll-Like Receptor 6 Drives Differentiation of Tolerogenic Dendritic Cells and Contributes to LcrV-Mediated Plague Pathogenesis . Cell Host and Microbe. 4. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 350-361.

DeBord, K.L., Anderson, D.M., Marketon, M.M., Overheim, K.A., DePaolo, R.W., Ciletti, N.A., Jabri, B., Schneewind, O.(2006). Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV . Infection and Immunity. 74. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4910-4914.

Overheim, K.A., DePaolo, R.W., Debord, K.L., Morrin, E.M., Anderson, D.M., Green, N.M., Brubaker, R.R., Jabri, B., Schneewind, O.(2005). LcrV plague vaccine with altered immunomodulatory properties . Infection and Immunity. 73. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5152-5159.

DePaolo, R.W., Lathan, R., Rollins, B.J., Karpus, W.J.(2005). The chemokine CCL2 is required for control of murine gastric Salmonella enterica infection . Infection and Immunity. 73. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6514-6522.

Marketon, M.M., DePaolo, R.W., DeBord, K.L., Jabri, B., Schneewind, O.(2005). Microbiology: Plague bacteria target immune cells during infection . Science. 309. (5741). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1739-1741.

DePaolo, R.W., Lathan, R., Karpus, W.J.(2004). CCR5 regulates high dose oral tolerance by modulating CC chemokine ligand 2 levels in the GALT . Journal of Immunology. 173. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 314-320.

DePaolo, R.W., Rollins, B.J., Kuziel, W., Karpus, W.J.(2003). CC chemokine ligand 2 and its receptor regulate mucosal production of IL-12 and TGF-β in high dose oral tolerance . Journal of Immunology. 171. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3560-3567.